Gene
ahcyl2a
- ID
- ZDB-GENE-070112-1522
- Name
- adenosylhomocysteinase like 2a
- Symbol
- ahcyl2a Nomenclature History
- Previous Names
-
- zgc:158222 (1)
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to enable adenosylhomocysteinase activity. Predicted to be involved in S-adenosylmethionine cycle. Predicted to act upstream of or within one-carbon metabolic process. Predicted to be active in cytosol. Orthologous to human AHCYL2 (adenosylhomocysteinase like 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Koslow et al., 2023
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR020082 | S-adenosyl-L-homocysteine hydrolase, conserved site |
| Domain | IPR015878 | S-adenosyl-L-homocysteine hydrolase, NAD binding domain |
| Family | IPR000043 | Adenosylhomocysteinase-like |
| Homologous_superfamily | IPR036291 | NAD(P)-binding domain superfamily |
| Homologous_superfamily | IPR042172 | Adenosylhomocysteinase-like superfamily |
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Domain Details Per Protein
| Protein | Length | Adenosylhomocysteinase-like | Adenosylhomocysteinase-like superfamily | NAD(P)-binding domain superfamily | S-adenosyl-L-homocysteine hydrolase, conserved site | S-adenosyl-L-homocysteine hydrolase, NAD binding domain |
|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9PMV0
|
515 | |||||
|
UniProtKB:K7DYH7
|
497 | |||||
|
UniProtKB:A0A8M2BIG2
|
516 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
zgc:158222-201
(1)
|
Ensembl | 777 nt | ||
| mRNA |
zgc:158222-202
(1)
|
Ensembl | 1,720 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-147K9 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:158222 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001080649 (1) | 1713 nt | ||
| Genomic | GenBank:CR788324 (1) | 193361 nt | ||
| Polypeptide | UniProtKB:A0A8M2BIG2 (1) | 516 aa |
- Koslow, M., Zhu, P., McCabe, C., Xu, X., Lin, X. (2023) Kidney transcriptome and cystic kidney disease genes in zebrafish. Frontiers in Physiology. 14:11840251184025
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Yan, S., Lu, Y., He, L., Zhao, X., Wu, L., Zhu, H., Jiang, M., Su, Y., Cao, W., Tian, W., Xing, Q. (2017) Dynamic Editome of Zebrafish under Aminoglycosides Treatment and Its Potential Involvement in Ototoxicity. Frontiers in pharmacology. 8:854
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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