Gene
trpm1a
- ID
- ZDB-GENE-070112-1372
- Name
- transient receptor potential cation channel, subfamily M, member 1a
- Symbol
- trpm1a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable calcium channel activity. Predicted to be involved in monoatomic cation transmembrane transport. Predicted to act upstream of or within several processes, including G protein-coupled glutamate receptor signaling pathway; detection of temperature stimulus; and protein tetramerization. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in optic furrow; presumptive retinal pigmented epithelium; retinal inner nuclear layer; and retinal pigmented epithelium. Human ortholog(s) of this gene implicated in congenital stationary night blindness and congenital stationary night blindness 1C. Orthologous to human TRPM1 (transient receptor potential cation channel subfamily M member 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa10436 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa10704 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa11580 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa15286 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa20961 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa30632 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa38616 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa40908 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa40909 | Allele with one point mutation | Unknown | Missense, Splice Site | ENU | |
| sa44666 | Allele with one point mutation | Unknown | Unknown | ENU |
1 - 10 of 10
Show
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| congenital stationary night blindness 1C | Alliance | Night blindness, congenital stationary (complete), 1C, autosomal recessive | 613216 |
1 - 1 of 1
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Ion transport domain | Transient receptor potential cation channel M | TRPM, SLOG domain | TRPM, tetramerisation domain | TRPM, tetramerisation domain superfamily |
|---|---|---|---|---|---|---|
|
UniProtKB:A1L239
|
319 | |||||
|
UniProtKB:A0A8M6Z7Q8
|
1647 | |||||
|
UniProtKB:A0A8M6YZ91
|
1552 | |||||
|
UniProtKB:E7FDL5
|
1546 | |||||
|
UniProtKB:A0A8M6Z1K6
|
1653 |
1 - 5 of 5
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
trpm1a-201
(1)
|
Ensembl | 5,842 nt | ||
| mRNA |
trpm1a-202
(1)
|
Ensembl | 964 nt | ||
| mRNA |
trpm1a-203
(1)
|
Ensembl | 1,351 nt | ||
| mRNA |
trpm1a-204
(1)
|
Ensembl | 872 nt |
1 - 4 of 4
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-112G6 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:158632 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191192 | ZFIN Curated Data |
1 - 3 of 3
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001316373 (1) | 4902 nt | ||
| Genomic | GenBank:CR456682 (1) | 193213 nt | ||
| Polypeptide | UniProtKB:A0A8M6Z1K6 (1) | 1653 aa |
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Seberg, H.E., Van Otterloo, E., Loftus, S.K., Liu, H., Bonde, G., Sompallae, R., Gildea, D.E., Santana, J.F., Manak, J.R., Pavan, W.J., Williams, T., Cornell, R.A. (2017) TFAP2 paralogs regulate melanocyte differentiation in parallel with MITF. PLoS Genetics. 13:e1006636
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Graham, D.M., Huang, L., Robinson, K.R., and Messerli, M.A. (2013) Epidermal keratinocyte polarity and motility require Ca2+ influx through TRPV1. Journal of Cell Science. 126(Pt 20):4602-13
- Kastenhuber, E., Gesemann, M., Mickoleit, M., and Neuhauss, S.C. (2013) Phylogenetic analysis and expression of zebrafish transient receptor potential melastatin family genes. Developmental Dynamics : an official publication of the American Association of Anatomists. 242(11):1236-49
- Braasch, I., Brunet, F., Volff, J.N., and Schartl, M. (2009) Pigmentation pathway evolution after whole-genome duplication in fish. Genome biology and evolution. 1:479-493
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
1 - 7 of 7
Show