Gene
cdt1
- ID
- ZDB-GENE-070111-1
- Name
- chromatin licensing and DNA replication factor 1
- Symbol
- cdt1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable DNA binding activity and DNA polymerase binding activity. Acts upstream of or within mitotic cell cycle. Predicted to be active in nucleus. Is expressed in several structures, including immature eye; mesoderm; proliferative region; pronephric duct; and somite. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 4. Orthologous to human CDT1 (chromatin licensing and DNA replication factor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7158083 (12 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Meier-Gorlin syndrome 4 | Alliance | Meier-Gorlin syndrome 4 | 613804 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR014939 | CDT1 Geminin-binding domain-like |
| Domain | IPR032054 | DNA replication factor Cdt1, C-terminal |
| Family | IPR045173 | DNA replication factor Cdt1 |
| Homologous_superfamily | IPR036390 | Winged helix DNA-binding domain superfamily |
| Homologous_superfamily | IPR038090 | DNA replication factor Cdt1, C-terminal WH domain superfamily |
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Domain Details Per Protein
| Protein | Length | CDT1 Geminin-binding domain-like | DNA replication factor Cdt1 | DNA replication factor Cdt1, C-terminal | DNA replication factor Cdt1, C-terminal WH domain superfamily | Winged helix DNA-binding domain superfamily |
|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M6YZJ1
|
628 | |||||
|
UniProtKB:E7F2R5
|
678 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-196P1 | ZFIN Curated Data | |
| Encodes | EST | fc37h07 | ||
| Encodes | EST | fi38h09 | ZFIN Curated Data | |
| Encodes | EST | fy23a12 | ||
| Encodes | EST | IMAGE:7158083 | Thisse et al., 2004 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_690072 (1) | 2482 nt | ||
| Genomic | GenBank:CR376726 (2) | 155854 nt | ||
| Polypeptide | UniProtKB:E7F2R5 (1) | 678 aa |
- Delgadillo-Silva, L.F., Tasöz, E., Singh, S.P., Chawla, P., Georgiadou, E., Gompf, A., Rutter, G.A., Ninov, N. (2024) Optogenetic β cell interrogation in vivo reveals a functional hierarchy directing the Ca2+ response to glucose supported by vitamin B6. Science advances. 10:eado4513eado4513
- He, Y., Wang, Y., Zhu, Y., Lo, L.J. (2023) Loss-of-function of zebrafish cdt1 causes retarded body growth and underdeveloped gonads resembling human Meier-Gorlin syndrome. Journal of Zhejiang University. Science. B. 24:103710461037-1046
- Alhashem, Z., Feldner-Busztin, D., Revell, C., Alvarez-Garcillan Portillo, M., Camargo-Sosa, K., Richardson, J., Rocha, M., Gauert, A., Corbeaux, T., Milanetto, M., Argenton, F., Tiso, N., Kelsh, R., Prince, V.E., Bentley, K., Linker, C. (2022) Notch controls the cell cycle to define leader versus follower identities during collective cell migration. eLIFE. 11:
- Liu, J., Zhang, M., Dong, H., Liu, J., Mao, A., Ning, G., Cao, Y., Zhang, Y., Wang, Q. (2022) Chemokine signaling synchronizes angioblast proliferation and differentiation during pharyngeal arch artery vasculogenesis. Development (Cambridge, England). 149(23):
- De Simone, A., Evanitsky, M.N., Hayden, L., Cox, B.D., Wang, J., Tornini, V.A., Ou, J., Chao, A., Poss, K.D., Di Talia, S. (2021) Control of osteoblast regeneration by a train of Erk activity waves. Nature. 590(7844):129-133
- Jerafi-Vider, A., Bassi, I., Moshe, N., Tevet, Y., Hen, G., Splittstoesser, D., Shin, M., Lawson, N.D., Yaniv, K. (2021) VEGFC/FLT4-induced cell-cycle arrest mediates sprouting and differentiation of venous and lymphatic endothelial cells. Cell Reports. 35:109255
- Sarvari, P., Rasouli, S.J., Allanki, S., Stone, O.A., Sokol, A., Graumann, J., Stainier, D.Y.R. (2021) The E3 ubiquitin-protein ligase Rbx1 regulates cardiac wall morphogenesis in zebrafish. Developmental Biology. 480:1-12
- Yang, Y., Wang, H., He, J., Shi, W., Jiang, Z., Gao, L., Jiang, Y., Ni, R., Yang, Q., Luo, L. (2021) A single-cell-resolution fate map of endoderm reveals demarcation of pancreatic progenitors by cell cycle. Proceedings of the National Academy of Sciences of the United States of America. 118(25):
- Zhang, W., Wu, C., Ni, R., Yang, Q., Luo, L., He, J. (2021) Formimidoyltransferase cyclodeaminase prevents the starvation-induced liver hepatomegaly and dysfunction through downregulating mTORC1. PLoS Genetics. 17:e1009980
- Ka, J., Kim, J.D., Pak, B., Han, O., Choi, W., Kim, H., Jin, S.W. (2020) Bone Morphogenetic Protein Signaling Restricts Proximodistal Extension of the Ventral Fin Fold. Frontiers in cell and developmental biology. 8:603306
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