Gene

ids

ID
ZDB-GENE-061215-37
Name
iduronate 2-sulfatase
Symbol
ids Nomenclature History
Previous Names
  • zgc:158245
Type
protein_coding_gene
Location
Chr: 14 Mapping Details/Browsers
Description
Exhibits iduronate-2-sulfatase activity. Involved in several processes, including cell surface receptor signaling pathway; heart trabecula formation; and skeletal system development. Localizes to cytoplasm. Used to study mucopolysaccharidosis II. Human ortholog(s) of this gene implicated in mucopolysaccharidosis II. Is expressed in several structures, including brain; digestive system; head; pectoral fin bud; and pleuroperitoneal region. Orthologous to human IDS (iduronate 2-sulfatase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Moro et al., 2010
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
10 figures from 4 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ids Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
mucopolysaccharidosis II Alliance Mucopolysaccharidosis II 309900
Associated With ids Via Experimental Models
Human Disease Fish Conditions Citations
mucopolysaccharidosis II ia10Tg; ia11Tg + MO1-ids standard conditions Costa et al., 2017
mucopolysaccharidosis II ia5Tg + MO1-ids standard conditions Costa et al., 2017
mucopolysaccharidosis II ia4Tg + MO1-ids standard conditions Costa et al., 2017
mucopolysaccharidosis II ia11Tg + MO1-ids standard conditions Costa et al., 2017
mucopolysaccharidosis II idsia200/ia200 standard conditions Bellesso et al., 2018
mucopolysaccharidosis II ia18Tg + MO1-ids standard conditions Costa et al., 2017
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR024607 Sulfatase, conserved site
Domain IPR000917 Sulfatase, N-terminal
Family IPR035874 Iduronate-2-sulfatase
Homologous_superfamily IPR017850 Alkaline-phosphatase-like, core domain superfamily
Domain Details Per Protein
Protein Length Alkaline-phosphatase-like, core domain superfamily Iduronate-2-sulfatase Sulfatase, conserved site Sulfatase, N-terminal
UniProtKB:A1A5V0
InterPro
561
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA ids-201 (1)
Ensembl
Ensembl 1,978 nt
ncRNA ids-002 (1)
Ensembl
Ensembl 779 nt
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations
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