Gene

kdm2aa

ID

ZDB-GENE-061215-144

Name

lysine (K)-specific demethylase 2Aa

Symbol

kdm2aa Nomenclature History

Previous Names

jhdm1A-b (1)
wu:fb76b11
wu:fj11c04
zgc:158441
zgc:158606

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Description

Predicted to have DNA binding activity and zinc ion binding activity. Involved in sex determination. Predicted to localize to nucleus. Used to study melanoma. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human KDM2A (lysine demethylase 2A).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 4 figures from Scahill et al., 2017
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With kdm2aa Human Ortholog

No data available

Associated With kdm2aa Via Experimental Models

Human Disease	Fish	Conditions	Citations
melanoma	kdm2aa^{sa9360/sa9360}	standard conditions	Scahill et al., 2017
melanoma	kdm2aa^sa898/sa898	standard conditions	Scahill et al., 2017

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001810	F-box domain
Domain	IPR001965	Zinc finger, PHD-type
Domain	IPR002857	Zinc finger, CXXC-type
Domain	IPR003347	JmjC domain
Domain	IPR019787	Zinc finger, PHD-finger
Domain	IPR041070	Jumonji, helical domain
Family	IPR050690	JHDM1 Histone Demethylase
Homologous_superfamily	IPR011011	Zinc finger, FYVE/PHD-type
Homologous_superfamily	IPR013083	Zinc finger, RING/FYVE/PHD-type
Homologous_superfamily	IPR032675	Leucine-rich repeat domain superfamily
Repeat	IPR006553	Leucine-rich repeat, cysteine-containing subtype

Domain Details Per Protein

Protein	Length	F-box domain	JHDM1 Histone Demethylase	JmjC domain	Jumonji, helical domain	Leucine-rich repeat, cysteine-containing subtype	Leucine-rich repeat domain superfamily	Zinc finger, CXXC-type	Zinc finger, FYVE/PHD-type	Zinc finger, PHD-finger	Zinc finger, PHD-type	Zinc finger, RING/FYVE/PHD-type
UniProtKB:A0A8M2B724 InterPro	1318
UniProtKB:A0A8M3AJC4 InterPro	1239
UniProtKB:A0A0R4IH56 InterPro	1295
UniProtKB:A0A8M3AK71 InterPro	1265
UniProtKB:A0A8M3B2Q2 InterPro	1293

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	kdm2aa-201 (1) Ensembl	Ensembl	3,806 nt	Select Tool
mRNA	kdm2aa-202 (1) Ensembl	Ensembl	4,843 nt	Select Tool
mRNA	kdm2aa-203 (1) Ensembl	Ensembl	5,010 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations