Gene
kdm2aa
- ID
- ZDB-GENE-061215-144
- Name
- lysine (K)-specific demethylase 2Aa
- Symbol
- kdm2aa Nomenclature History
- Previous Names
-
- jhdm1A-b (1)
- wu:fb76b11
- wu:fj11c04
- zgc:158441
- zgc:158606
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable histone demethylase activity and transcription coregulator activity. Acts upstream of or within sex determination. Predicted to be located in nucleus. Used to study melanoma. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human KDM2A (lysine demethylase 2A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 4 figures from Scahill et al., 2017
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la021217Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa898 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa9360 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa18702 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| zko854b | Allele with one delins | Unknown | Unknown | CRISPR |
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Human Disease
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| melanoma | kdm2aasa9360/sa9360 | standard conditions | Scahill et al., 2017 |
| melanoma | kdm2aasa898/sa898 | standard conditions | Scahill et al., 2017 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | F-box domain | JHDM1 Histone Demethylase | JmjC domain | Jumonji, helical domain | Leucine-rich repeat, cysteine-containing subtype | Leucine-rich repeat domain superfamily | Zinc finger, CXXC-type | Zinc finger, FYVE/PHD-type | Zinc finger, PHD-finger | Zinc finger, PHD-type | Zinc finger, RING/FYVE/PHD-type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M2B724
|
1318 | |||||||||||
|
UniProtKB:A0A8M3AJC4
|
1239 | |||||||||||
|
UniProtKB:A0A0R4IH56
|
1295 | |||||||||||
|
UniProtKB:A0A8M3AK71
|
1265 | |||||||||||
|
UniProtKB:A0A8M3B2Q2
|
1293 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
kdm2aa-201
(1)
|
Ensembl | 3,806 nt | ||
| mRNA |
kdm2aa-202
(1)
|
Ensembl | 4,843 nt | ||
| mRNA |
kdm2aa-203
(1)
|
Ensembl | 5,010 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-9I23 | ZFIN Curated Data | |
| Encodes | EST | fb76b11 | ||
| Encodes | EST | fj11c04 | ||
| Encodes | cDNA | MGC:158441 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:158606 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001081692 (1) | 5010 nt | ||
| Genomic | GenBank:BX901937 (1) | 204746 nt | ||
| Polypeptide | UniProtKB:A0A8M2B724 (1) | 1318 aa |
- White, R.J., Mackay, E., Wilson, S.W., Busch-Nentwich, E.M. (2022) Allele-specific gene expression can underlie altered transcript abundance in zebrafish mutants. eLIFE. 11:
- Fellous, A., Earley, R.L., Silvestre, F. (2018) The Kdm/Kmt gene families in the self-fertilizing mangrove rivulus fish, Kryptolebias marmoratus, suggest involvement of histone methylation machinery in development and reproduction. Gene. 687:173-187
- Yu, S.H., Zhu, K.Y., Zhang, F., Wang, J., Yuan, H., Chen, Y., Jin, Y., Dong, M., Wang, L., Jia, X.E., Gao, L., Dong, Z.W., Ren, C.G., Chen, L.T., Huang, Q.H., Deng, M., Zon, L.I., Zhou, Y., Zhu, J., Xu, P.F., Liu, T.X. (2018) The histone demethylase Jmjd3 regulates zebrafish myeloid development by promoting spi1 expression. Biochimica et biophysica acta. 1861(2):106-116
- Zhang, J., Zhou, Y., Wu, C., Wan, Y., Fang, C., Li, J., Fang, W., Yi, R., Zhu, G., Li, J., Wang, Y. (2018) Characterization of the Apelin/Elabela Receptors (APLNR) in Chickens, Turtles, and Zebrafish: Identification of a Novel Apelin-Specific Receptor in Teleosts. Frontiers in endocrinology. 9:756
- Borgel, J., Tyl, M., Schiller, K., Pusztai, Z., Dooley, C.M., Deng, W., Wooding, C., White, R.J., Warnecke, T., Leonhardt, H., Busch-Nentwich, E.M., Bartke, T. (2017) KDM2A integrates DNA and histone modification signals through a CXXC/PHD module and direct interaction with HP1. Nucleic acids research. 45:1114-1129
- Scahill, C.M., Digby, Z., Sealy, I.M., Wojciechowska, S., White, R.J., Collins, J.E., Stemple, D.L., Bartke, T., Mathers, M.E., Patton, E.E., Busch-Nentwich, E.M. (2017) Loss of the chromatin modifier Kdm2aa causes BrafV600E-independent spontaneous melanoma in zebrafish. PLoS Genetics. 13:e1006959
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
- Kucenas, S., Li, Z., Cox, J.A., Egan, T.M., and Voigt, M.M. (2003) Molecular characterization of the zebrafish P2X receptor subunit gene family. Neuroscience. 121(4):935-945
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