Gene

papss2a

ID

ZDB-GENE-061110-85

Name

3'-phosphoadenosine 5'-phosphosulfate synthase 2a

Symbol

papss2a Nomenclature History

Previous Names

zgc:153748

Type

protein_coding_gene

Location

Chr: 17 Mapping Details/Browsers

Description

Predicted to have ATP binding activity; adenylylsulfate kinase activity; and sulfate adenylyltransferase (ATP) activity. Predicted to be involved in 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process and sulfate assimilation. Human ortholog(s) of this gene implicated in spondyloepimetaphyseal dysplasia, Pakistani type. Orthologous to human PAPSS2 (3'-phosphoadenosine 5'-phosphosulfate synthase 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Gonzalez et al., 2017

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With papss2a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
spondyloepimetaphyseal dysplasia, Pakistani type	Alliance	Brachyolmia 4 with mild epiphyseal and metaphyseal changes	612847

Associated With papss2a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR024951	Sulphate adenylyltransferase catalytic domain
Domain	IPR025980	ATP-sulfurylase PUA-like domain
Family	IPR002650	Sulphate adenylyltransferase
Family	IPR002891	Adenylyl-sulfate kinase
Homologous_superfamily	IPR014729	Rossmann-like alpha/beta/alpha sandwich fold
Homologous_superfamily	IPR015947	PUA-like superfamily
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase