Gene
adcy2a
- ID
- ZDB-GENE-061109-1
- Name
- adenylate cyclase 2a
- Symbol
- adcy2a Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to enable adenylate cyclase activity. Acts upstream of or within atrioventricular canal development and determination of heart left/right asymmetry. Predicted to be located in membrane. Predicted to be active in plasma membrane. Used to study congenital heart disease. Orthologous to human ADCY2 (adenylate cyclase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Izarzugaza et al., 2020
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-adcy2a | N/A | Izarzugaza et al., 2020 |
| MO2-adcy2a | N/A | Izarzugaza et al., 2020 |
1 - 2 of 2
Show
Human Disease
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| congenital heart disease | AB/TL + MO1-adcy2a | standard conditions | Izarzugaza et al., 2020 |
1 - 1 of 1
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018297 | Adenylyl cyclase class-4/guanylyl cyclase, conserved site |
| Domain | IPR001054 | Adenylyl cyclase class-3/4/guanylyl cyclase |
| Domain | IPR009398 | Adenylate cyclase, conserved domain |
| Domain | IPR032628 | Adenylate cyclase, N-terminal |
| Family | IPR030672 | Adenylate cyclase |
1 - 5 of 6 Show all
Domain Details Per Protein
| Protein | Length | Adenylate cyclase | Adenylate cyclase, conserved domain | Adenylate cyclase, N-terminal | Adenylyl cyclase class-3/4/guanylyl cyclase | Adenylyl cyclase class-4/guanylyl cyclase, conserved site | Nucleotide cyclase |
|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9PC26
|
197 | ||||||
|
UniProtKB:A0A8N7TBA8
|
1155 | ||||||
|
UniProtKB:A0A8M9NZK7
|
1101 | ||||||
|
UniProtKB:A0A8M2B4W1
|
900 |
1 - 4 of 4
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
adcy2a-201
(1)
|
Ensembl | 4,102 nt | ||
| mRNA |
adcy2a-202
(1)
|
Ensembl | 3,267 nt |
1 - 2 of 2
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-119D19 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-11F7 | ZFIN Curated Data |
1 - 2 of 2
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_687081 (1) | 4064 nt | ||
| Genomic | GenBank:BX324207 (1) | 187152 nt | ||
| Polypeptide | UniProtKB:A0A8N7TBA8 (1) | 1155 aa |
- Mao, K., Li, X., Chen, Z., Dong, X., Zhangsun, D., Zhu, X., Luo, S. (2022) α-Conotoxin TxIB Improved Behavioral Abnormality and Changed Gene Expression in Zebrafish (Danio rerio) Induced by Alcohol Withdrawal. Frontiers in pharmacology. 13:802917
- Izarzugaza, J.M.G., Ellesøe, S.G., Doganli, C., Ehlers, N.S., Dalgaard, M.D., Audain, E., Dombrowsky, G., Banasik, K., Sifrim, A., Wilsdon, A., Thienpont, B., Breckpot, J., Gewillig, M., Competence Network for Congenital Heart Defects, Germany, Brook, J.D., Hitz, M.P., Larsen, L.A., Brunak, S. (2020) Systems genetics analysis identifies calcium-signaling defects as novel cause of congenital heart disease. Genome Medicine. 12:76
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Dildrop, R., and Ruther, U. (2004) Organization of Iroquois genes in fish. Development genes and evolution. 214(6):267-276
1 - 4 of 4
Show