Gene

adcy2a

ID

ZDB-GENE-061109-1

Name

adenylate cyclase 2a

Symbol

adcy2a Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 16 Mapping Details/Browsers

Description

Predicted to have adenylate cyclase activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to localize to integral component of plasma membrane. Orthologous to human ADCY2 (adenylate cyclase 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Izarzugaza et al., 2020
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With adcy2a Human Ortholog

No data available

Associated With adcy2a Via Experimental Models

Human Disease	Fish	Conditions	Citations
congenital heart disease	AB/TL + MO1-adcy2a	standard conditions	Izarzugaza et al., 2020

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018297	Adenylyl cyclase class-4/guanylyl cyclase, conserved site
Domain	IPR001054	Adenylyl cyclase class-3/4/guanylyl cyclase
Domain	IPR009398	Adenylate cyclase, conserved domain
Domain	IPR032628	Adenylate cyclase, N-terminal
Family	IPR030672	Adenylate cyclase
Homologous_superfamily	IPR029787	Nucleotide cyclase

Domain Details Per Protein

Protein	Length	Adenylate cyclase	Adenylate cyclase, conserved domain	Adenylate cyclase, N-terminal	Adenylyl cyclase class-3/4/guanylyl cyclase	Adenylyl cyclase class-4/guanylyl cyclase, conserved site	Nucleotide cyclase
UniProtKB:A0A8M9PC26 InterPro	197
UniProtKB:A0A8N7TBA8 InterPro	1155
UniProtKB:A0A8M9NZK7 InterPro	1101
UniProtKB:A0A8M2B4W1 InterPro	900

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	adcy2a-201 (1) Ensembl	Ensembl		4,102 nt	Select Tool
mRNA	adcy2a-202 (1) Ensembl	Ensembl		3,267 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations