Gene

telo2

ID

ZDB-GENE-061103-523

Name

TEL2, telomere maintenance 2, homolog (S. cerevisiae)

Symbol

telo2 Nomenclature History

Previous Names

si:ch211-153c20.2
zgc:153824 (1)

Type

protein_coding_gene

Location

Chr: 24 Mapping Details/Browsers

Description

Predicted to have Hsp90 protein binding activity and telomeric DNA binding activity. Predicted to be involved in protein stabilization and telomere maintenance via telomerase. Predicted to localize to several cellular components, including TORC1 complex; TORC2 complex; and nuclear chromosome. Orthologous to human TELO2 (telomere maintenance 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Liu et al., 2021

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Shin et al., 2021
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With telo2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		You-Hoover-Fong syndrome	616954

Associated With telo2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR019337	Telomere length regulation protein, conserved domain
Family	IPR051970	Telomere Length Regulation TEL2
Homologous_superfamily	IPR038528	TEL2, C-terminal domain superfamily