Gene

sfrp2

ID

ZDB-GENE-061013-293

Name

secreted frizzled-related protein 2

Symbol

sfrp2 Nomenclature History

Previous Names

hm:zeh0225
sb:eu233
zeh0225
zgc:153618

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Description

Predicted to enable Wnt-protein binding activity. Predicted to be involved in canonical Wnt signaling pathway and non-canonical Wnt signaling pathway. Predicted to act upstream of or within Wnt signaling pathway and cell differentiation. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including adaxial cell; axis; ectoderm; head; and musculature system. Orthologous to human SFRP2 (secreted frizzled related protein 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

15 figures from 9 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

eu233 (15 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Zhu et al., 2018
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With sfrp2 Human Ortholog

No data available

Associated With sfrp2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001134	Netrin domain
Domain	IPR018933	Netrin module, non-TIMP type
Domain	IPR020067	Frizzled domain
Domain	IPR041764	SFRP2, cysteine-rich domain
Family	IPR015526	Frizzled/secreted frizzled-related protein
Homologous_superfamily	IPR008993	Tissue inhibitor of metalloproteinases-like, OB-fold
Homologous_superfamily	IPR036790	Frizzled cysteine-rich domain superfamily