Gene

il1rapl1a

ID

ZDB-GENE-061013-249

Name

interleukin 1 receptor accessory protein-like 1a

Symbol

il1rapl1a Nomenclature History

Previous Names

fi18g04
wu:fi18g04
zgc:152866 (1)

Type

protein_coding_gene

Location

Chr: 9 Mapping Details/Browsers

Description

Predicted to enable NAD(P)+ nucleosidase activity; NAD+ nucleotidase, cyclic ADP-ribose generating; and interleukin-1 receptor activity. Predicted to be involved in negative regulation of exocytosis. Predicted to act upstream of or within signal transduction. Predicted to be located in cytoplasm and plasma membrane. Is expressed in optic tectum and telencephalon. Human ortholog(s) of this gene implicated in intellectual disability and non-syndromic X-linked intellectual disability 21. Orthologous to human IL1RAPL1 (interleukin 1 receptor accessory protein like 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Yoshida et al., 2008

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With il1rapl1a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
non-syndromic X-linked intellectual disability 21	Alliance	Intellectual developmental disorder, X-linked 21	300143

Associated With il1rapl1a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000157	Toll/interleukin-1 receptor homology (TIR) domain
Domain	IPR000477	Reverse transcriptase domain
Domain	IPR001584	Integrase, catalytic core
Domain	IPR003598	Immunoglobulin subtype 2
Domain	IPR003599	Immunoglobulin domain subtype
Domain	IPR007110	Immunoglobulin-like domain
Domain	IPR041577	Reverse transcriptase/retrotransposon-derived protein, RNase H-like domain
Domain	IPR041588	Integrase zinc-binding domain
Family	IPR004074	Interleukin-1 receptor type I/II
Family	IPR015621	Interleukin-1 receptor family
Family	IPR050951	Retrovirus-related Pol polyprotein
Homologous_superfamily	IPR012337	Ribonuclease H-like superfamily
Homologous_superfamily	IPR013783	Immunoglobulin-like fold
Homologous_superfamily	IPR021109	Aspartic peptidase domain superfamily
Homologous_superfamily	IPR035897	Toll/interleukin-1 receptor homology (TIR) domain superfamily
Homologous_superfamily	IPR036179	Immunoglobulin-like domain superfamily
Homologous_superfamily	IPR036397	Ribonuclease H superfamily
Homologous_superfamily	IPR043128	Reverse transcriptase/Diguanylate cyclase domain
Homologous_superfamily	IPR043502	DNA/RNA polymerase superfamily