Gene

aplp2

ID

ZDB-GENE-061009-28

Name

amyloid beta (A4) precursor-like protein 2

Symbol

aplp2 Nomenclature History

Previous Names

fk52a05
si:dkey-11k4.3
wu:fk52a05

Type

protein_coding_gene

Location

Chr: 18 Mapping Details/Browsers

Description

Predicted to have heparin binding activity; serine-type endopeptidase inhibitor activity; and transition metal ion binding activity. Predicted to localize to integral component of membrane. Is expressed in gill; heart; liver; nervous system; and pleuroperitoneal region. Orthologous to human APLP2 (amyloid beta precursor like protein 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

5 figures from 4 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With aplp2 Human Ortholog

No data available

Associated With aplp2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR019744	Amyloidogenic glycoprotein, copper-binding domain conserved site
Conserved_site	IPR019745	Amyloidogenic glycoprotein, intracellular domain, conserved site
Conserved_site	IPR020901	Proteinase inhibitor I2, Kunitz, conserved site
Domain	IPR002223	Pancreatic trypsin inhibitor Kunitz domain
Domain	IPR008154	Amyloidogenic glycoprotein, extracellular
Domain	IPR011178	Amyloidogenic glycoprotein, copper-binding
Domain	IPR015849	Amyloidogenic glycoprotein, heparin-binding
Domain	IPR019543	Beta-amyloid precursor protein C-terminal
Domain	IPR024329	Amyloidogenic glycoprotein, E2 domain
Family	IPR008155	Amyloidogenic glycoprotein
Homologous_superfamily	IPR011993	PH-like domain superfamily
Homologous_superfamily	IPR036176	E2 domain superfamily
Homologous_superfamily	IPR036454	Amyloidogenic glycoprotein, heparin-binding domain superfamily
Homologous_superfamily	IPR036669	Amyloidogenic glycoprotein, copper-binding domain superfamily
Homologous_superfamily	IPR036880	Pancreatic trypsin inhibitor Kunitz domain superfamily

Domain Details Per Protein

Protein	Length	Amyloidogenic glycoprotein	Amyloidogenic glycoprotein, copper-binding	Amyloidogenic glycoprotein, copper-binding domain conserved site	Amyloidogenic glycoprotein, copper-binding domain superfamily	Amyloidogenic glycoprotein, E2 domain	Amyloidogenic glycoprotein, extracellular	Amyloidogenic glycoprotein, heparin-binding	Amyloidogenic glycoprotein, heparin-binding domain superfamily	Amyloidogenic glycoprotein, intracellular domain, conserved site	Beta-amyloid precursor protein C-terminal	E2 domain superfamily	Pancreatic trypsin inhibitor Kunitz domain	Pancreatic trypsin inhibitor Kunitz domain superfamily	PH-like domain superfamily	Proteinase inhibitor I2, Kunitz, conserved site
UniProtKB:A0A8M9P166 InterPro	757
UniProtKB:A0A2R8Q4V0 InterPro	776
UniProtKB:A2BID8 InterPro PDB	764
UniProtKB:A0A8M9PA77 InterPro	745
UniProtKB:A0A8M9PFK9 InterPro	720