Gene
iba57
- ID
- ZDB-GENE-060929-712
- Name
- iron-sulfur cluster assembly factor IBA57
- Symbol
- iba57 Nomenclature History
- Previous Names
-
- zgc:153540
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Involved in heme biosynthetic process. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 74 and multiple mitochondrial dysfunctions syndrome 3. Is expressed in intermediate cell mass of mesoderm. Orthologous to human IBA57 (iron-sulfur cluster assembly factor IBA57).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Nilsson et al., 2009
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Nilsson et al., 2009
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hereditary spastic paraplegia 74 | Alliance | ?Spastic paraplegia 74, autosomal recessive | 616451 |
| multiple mitochondrial dysfunctions syndrome 3 | Alliance | Multiple mitochondrial dysfunctions syndrome 3 | 615330 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | GTP-binding protein TrmE/Aminomethyltransferase GcvT, domain 1 | YgfZ/GcvT | YgfZ/GcvT conserved site |
|---|---|---|---|---|
|
UniProtKB:B8JMH0
|
Interactions and Pathways
No data available
Plasmids
No data available