Gene
dync1i2a
- ID
- ZDB-GENE-060929-1086
- Name
- dynein, cytoplasmic 1, intermediate chain 2a
- Symbol
- dync1i2a Nomenclature History
- Previous Names
-
- dync1i2
- im:7147021
- zgc:153318
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to contribute to ATP-dependent microtubule motor activity, plus-end-directed. Predicted to be involved in positive regulation of ATP-dependent microtubule motor activity, plus-end-directed and transport along microtubule. Predicted to localize to cytoplasmic dynein complex. Used to study primary autosomal recessive microcephaly. Orthologous to human DYNC1I2 (dynein cytoplasmic 1 intermediate chain 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7147021 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Ansar et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Neurodevelopmental disorder with microcephaly and structural brain anomalies | 618492 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR025956 | Cytoplasmic dynein 1 intermediate chain 1/2 |
| Family | IPR050687 | Dynein Intermediate Chain |
| Homologous_superfamily | IPR015943 | WD40/YVTN repeat-like-containing domain superfamily |
| Homologous_superfamily | IPR036322 | WD40-repeat-containing domain superfamily |
| Repeat | IPR001680 | WD40 repeat |
Domain Details Per Protein
| Protein | Length | Cytoplasmic dynein 1 intermediate chain 1/2 | Dynein Intermediate Chain | WD40 repeat | WD40-repeat-containing domain superfamily | WD40/YVTN repeat-like-containing domain superfamily |
|---|---|---|---|---|---|---|
|
UniProtKB:Q08CA8
|
471 | |||||
|
UniProtKB:A0A8M6Z827
|
626 | |||||
|
UniProtKB:A0A286YAG4
|
608 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
dync1i2a-201
(1)
|
Ensembl | 5,406 nt | ||
| mRNA |
dync1i2a-202
(1)
|
Ensembl | 1,038 nt | ||
| mRNA |
dync1i2a-203
(1)
|
Ensembl | 984 nt | ||
| mRNA |
dync1i2a-204
(1)
|
Ensembl | 1,912 nt | ||
| mRNA |
dync1i2a-205
(1)
|
Ensembl | 4,307 nt | ||
| mRNA |
dync1i2a-206
(1)
|
Ensembl | 5,352 nt | ||
| mRNA | si:ch1073-276n13.1-001 (1) | 1,038 nt |
Interactions and Pathways
No data available
Plasmids
No data available