Gene

bmp1a

ID
ZDB-GENE-060818-1
Name
bone morphogenetic protein 1a
Symbol
bmp1a Nomenclature History
Previous Names
  • frf
  • frilly fins
  • unm t31169
  • unm_t31169
  • wdd
Type
protein_coding_gene
Location
Chr: 8 Mapping Details/Browsers
Description
Enables peptidase activity. Acts upstream of or within several processes, including collagen biosynthetic process; determination of ventral identity; and protein phosphopantetheinylation. Predicted to be active in extracellular space. Is expressed in several structures, including alar plate midbrain region; central nervous system; mesenchyme median fin fold; mesoderm; and optic vesicle. Used to study osteogenesis imperfecta and osteogenesis imperfecta type 13. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 13. Orthologous to human BMP1 (bone morphogenetic protein 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
7 figures from 6 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
28 figures from 11 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With bmp1a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
osteogenesis imperfecta type 13 Alliance Osteogenesis imperfecta, type XIII 614856
1 - 1 of 1
Associated With bmp1a Via Experimental Models
Human Disease Fish Conditions Citations
osteogenesis imperfecta type 13 bmp1asa2416/sa2416 standard conditions (2)
osteogenesis imperfecta bmp1atp34/tp34 standard conditions Tomecka et al., 2019
osteogenesis imperfecta bmp1asa2416/sa2416 standard conditions Hur et al., 2017
1 - 3 of 3
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018097 EGF-like calcium-binding, conserved site
Domain IPR000742 EGF-like domain
Domain IPR000859 CUB domain
Domain IPR001506 Peptidase M12A
Domain IPR001881 EGF-like calcium-binding domain
1 - 5 of 12 Show all
Domain Details Per Protein
Protein Length Bone morphogenetic protein 1/tolloid-like protein CUB domain EGF-like calcium-binding, conserved site EGF-like calcium-binding domain EGF-like domain EGF-type aspartate/asparagine hydroxylation site Metallopeptidase, catalytic domain superfamily NOTCH1 EGF-like calcium-binding domain Peptidase M12A Peptidase, metallopeptidase Spermadhesin, CUB domain superfamily Tolloid/BMP1 peptidase domain
UniProtKB:F1REM3
InterPro
976
UniProtKB:Q2ABP1
InterPro
986
1 - 2 of 2
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA bmp1a-201 (1)
Ensembl
Ensembl 3,734 nt
ZFIN BLAST
mRNA bmp1a-202 (1)
Ensembl
Ensembl 3,212 nt
ZFIN BLAST
1 - 2 of 2
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations
Your Input Welcome
We welcome your input and comments. Please use this form to recommend updates to the information in ZFIN. We appreciate as much detail as possible and references as appropriate. We will review your comments promptly.