Gene

ctnna2

ID

ZDB-GENE-060815-3

Name

catenin (cadherin-associated protein), alpha 2

Symbol

ctnna2 Nomenclature History

Previous Names

im:5410539
si:rp71-1h10.1

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Description

Predicted to have actin filament binding activity; cadherin binding activity; and structural molecule activity. Predicted to be involved in several processes, including brain morphogenesis; neuron projection morphogenesis; and regulation of synapse structural plasticity. Predicted to localize to adherens junction; axon; and cytoplasm. Human ortholog(s) of this gene implicated in complex cortical dysplasia with other brain malformations. Is expressed in female organism. Orthologous to human CTNNA2 (catenin alpha 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

eu764 (1 image)
IMAGE:5410539 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ctnna2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Cortical dysplasia, complex, with other brain malformations 9	618174

Associated With ctnna2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR000633	Vinculin, conserved site
Family	IPR001033	Alpha-catenin
Family	IPR006077	Vinculin/alpha-catenin
Homologous_superfamily	IPR036723	Alpha-catenin/vinculin-like superfamily

Domain Details Per Protein

Protein	Length	Alpha-catenin	Alpha-catenin/vinculin-like superfamily	Vinculin/alpha-catenin	Vinculin, conserved site
UniProtKB:B7ZC77 InterPro	865
UniProtKB:A0A8M2B6X9 InterPro	905

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	ctnna2-201 (1) Ensembl	Ensembl	3,382 nt	Select Tool ZFIN BLAST
mRNA	ctnna2-202 (1) Ensembl	Ensembl	1,683 nt	Select Tool ZFIN BLAST
mRNA	ctnna2-204 (1) Ensembl	Ensembl	1,560 nt	Select Tool ZFIN BLAST
mRNA	ctnna2-205 (1) Ensembl	Ensembl	899 nt	Select Tool ZFIN BLAST
mRNA	ctnna2-207 (1) Ensembl	Ensembl	7,103 nt	Select Tool ZFIN BLAST
mRNA	ctnna2-208 (1) Ensembl	Ensembl	4,684 nt	Select Tool ZFIN BLAST
mRNA	ctnna2-209 (1) Ensembl	Ensembl	6,141 nt	Select Tool ZFIN BLAST
ncRNA	ctnna2-004 (1) Ensembl	Ensembl	554 nt	Select Tool ZFIN BLAST
ncRNA	ctnna2-005 (1) Ensembl	Ensembl	822 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations