Gene
lratb.1
- ID
- ZDB-GENE-060810-31
- Name
- lecithin retinol acyltransferase b, tandem duplicate 1
- Symbol
- lratb.1 Nomenclature History
- Previous Names
-
- lratb
- im:7148552
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Enables phosphatidylcholine-retinol O-acyltransferase activity. Acts upstream of or within retinol metabolic process. Predicted to be located in membrane. Predicted to be active in rough endoplasmic reticulum. Is expressed in several structures, including central nervous system; hindbrain neural keel; margin; mesoderm; and neural crest. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 14 and retinitis pigmentosa. Orthologous to human LRAT (lecithin retinol acyltransferase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7148552 (21 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Isken et al., 2007
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| fh260 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| la021366Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| lratb.1_unrecovered | Allele with one point mutation | Unknown | Unknown | ENU | |
| sa1600 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Leber congenital amaurosis 14 | Alliance | Leber congenital amaurosis 14 | 613341 |
| Leber congenital amaurosis 14 | Alliance | Retinal dystrophy, early-onset severe | 613341 |
| Leber congenital amaurosis 14 | Alliance | Retinitis pigmentosa, juvenile | 613341 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR010839 | Acyclic terpene utilisation |
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Domain Details Per Protein
| Protein | Length | Acyclic terpene utilisation |
|---|---|---|
|
UniProtKB:A0A8M9Q803
|
642 | |
|
UniProtKB:A0A0R4IX64
|
679 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
lratb.1-201
(1)
|
Ensembl | 998 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-132F6 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:7148552 | Thisse et al., 2004 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | GenBank:BC090301 (1) | 1000 nt | ||
| Genomic | GenBank:CU861508 | 66282 nt | ||
| Polypeptide | UniProtKB:A0A0R4IX64 (1) | 679 aa |
- Cooper, T.K., Murray, K.N., Spagnoli, S., Spitsbergen, J.M. (2015) Primary Intestinal and Vertebral Chordomas in Laboratory Zebrafish (Danio rerio). Veterinary Pathology. 52(2):388-92
- Kok, F.O., Shin, M., Ni, C., Gupta, A., Grosse, A.S., van Impel, A., Kirchmaier, B.C., Peterson-Maduro, J., Kourkoulis, G., Male, I., DeSantis, D.F., Sheppard-Tindell, S., Ebarasi, L., Betsholtz, C., Schulte-Merker, S., Wolfe, S.A., Lawson, N.D. (2015) Reverse Genetic Screening Reveals Poor Correlation between Morpholino-Induced and Mutant Phenotypes in Zebrafish. Developmental Cell. 32(1):97-108
- Heyn, P., Kircher, M., Dahl, A., Kelso, J., Tomancak, P., Kalinka, A.T., and Neugebauer, K.M. (2014) The earliest transcribed zygotic genes are short, newly evolved, and different across species. Cell Reports. 6(2):285-292
- Zhang, M., Kothari, P., Mullins, M., Lampson, M.A. (2014) Regulation of zygotic genome activation and DNA damage checkpoint acquisition at the mid-blastula transition. Cell cycle (Georgetown, Tex.). 13:3828-38
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Isken, A., Holzschuh, J., Lampert, J.M., Fischer, L., Oberhauser, V., Palczewski, K., and von Lintig, J. (2007) Sequestration of retinyl esters is essential for retinoid signaling in the zebrafish embryo. The Journal of biological chemistry. 282(2):1144-1151
- O'Boyle, S., Bree, R.T., McLoughlin, S., Grealy, M., and Byrnes, L. (2007) Identification of zygotic genes expressed at the midblastula transition in zebrafish. Biochemical and Biophysical Research Communications. 358(2):462-468
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
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