Gene

wdr35

ID

ZDB-GENE-060810-148

Name

WD repeat domain 35

Symbol

wdr35 Nomenclature History

Previous Names

im:7159945 (1)
si:ch211-206k20.4

Type

protein_coding_gene

Location

Chr: 13 Mapping Details/Browsers

Description

Involved in cilium assembly. Predicted to localize to axoneme and intraciliary transport particle A. Human ortholog(s) of this gene implicated in Ellis-Van Creveld syndrome; Sensenbrenner syndrome; and short-rib thoracic dysplasia 7 with or without polydactyly. Orthologous to human WDR35 (WD repeat domain 35).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7159945 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Stawicki et al., 2016
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With wdr35 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
cranioectodermal dysplasia 2	Alliance	Cranioectodermal dysplasia 2	613610
short-rib thoracic dysplasia 7 with or without polydactyly	Alliance	Short-rib thoracic dysplasia 7 with or without polydactyly	614091

Associated With wdr35 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR024977	Anaphase-promoting complex subunit 4-like, WD40 domain
Family	IPR017233	WD repeat protein 35
Family	IPR039857	Intraflagellar transport protein 122/121 homolog
Homologous_superfamily	IPR015943	WD40/YVTN repeat-like-containing domain superfamily
Homologous_superfamily	IPR036322	WD40-repeat-containing domain superfamily
Repeat	IPR001680	WD40 repeat

Domain Details Per Protein

Protein	Length	Anaphase-promoting complex subunit 4-like, WD40 domain	Intraflagellar transport protein 122/121 homolog	WD40 repeat	WD40-repeat-containing domain superfamily	WD40/YVTN repeat-like-containing domain superfamily	WD repeat protein 35
UniProtKB:A0A8M9Q9T9 InterPro	1184
UniProtKB:B7ZD88 InterPro	1203

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
aberrant processed transcript	wdr35-203 (1) Ensembl	Ensembl	800 nt	Select Tool
mRNA	wdr35-201 (1) Ensembl	Ensembl	4,088 nt	Select Tool
ncRNA	wdr35-003 (1) Ensembl	Ensembl	584 nt	Select Tool
ncRNA	wdr35-004 (1) Ensembl	Ensembl	865 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations