Gene

ank3a

ID

ZDB-GENE-060621-1

Name

ankyrin 3a

Symbol

ank3a Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 17 Mapping Details/Browsers

Description

Predicted to be involved in signal transduction. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human ANK3 (ankyrin 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Owen et al., 2022
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ank3a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autosomal recessive intellectual developmental disorder 37	Alliance	Intellectual developmental disorder, autosomal recessive 37	615493

Associated With ank3a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000488	Death domain
Domain	IPR000906	ZU5 domain
Domain	IPR037971	Ankyrin-3, death domain
Domain	IPR040745	Ankyrin, UPA domain
Family	IPR051165	Multifunctional Ankyrin Repeat Domain-Containing Protein
Homologous_superfamily	IPR011029	Death-like domain superfamily
Homologous_superfamily	IPR036770	Ankyrin repeat-containing domain superfamily
Repeat	IPR002110	Ankyrin repeat

Domain Details Per Protein

Protein	Length	Ankyrin-3, death domain	Ankyrin repeat	Ankyrin repeat-containing domain superfamily	Ankyrin, UPA domain	Death domain	Death-like domain superfamily	Multifunctional Ankyrin Repeat Domain-Containing Protein	ZU5 domain
UniProtKB:A0A8M9Q287 InterPro	4486
UniProtKB:A0A8M3AJS7 InterPro	3692
UniProtKB:A0A8M9PVB2 InterPro	4463
UniProtKB:A0A8M3AR97 InterPro	4499
UniProtKB:A0A8M3ARB3 InterPro	4180
UniProtKB:A0A8M3ARA9 InterPro	4466
UniProtKB:A0A8M9PCL5 InterPro	4482
UniProtKB:A0A8M3B2C4 InterPro	4066
UniProtKB:A0A8M9Q6F7 InterPro	3692
UniProtKB:A0A8M3B2A9 InterPro	4491
UniProtKB:A0A8M9PET0 InterPro	4494
UniProtKB:A0A8M3AIX2 InterPro	4103
UniProtKB:A0A8M9PPF5 InterPro	4483
UniProtKB:A0A8M3B2B6 InterPro	4478
UniProtKB:A0A8M3AIV4 InterPro	4498
UniProtKB:A0A8M3AJR3 InterPro	4488
UniProtKB:A0A8M3ARB6 InterPro	1790
UniProtKB:A0A8M3AJR9 InterPro	4474
UniProtKB:A0A8M3AU79 InterPro	2109
UniProtKB:A0A8M9Q6F2 InterPro	4498
UniProtKB:A0A8M3AU68 InterPro	4472
UniProtKB:A0A8M3ARA5 InterPro	4486
UniProtKB:A0A8M9P0J3 InterPro	2098
UniProtKB:A0A8M3AU73 InterPro	4201
UniProtKB:A0A8M3AJS3 InterPro	4405

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	ank3a-201 (1) Ensembl	Ensembl	5,313 nt	Select Tool ZFIN BLAST
mRNA	ank3a-202 (1) Ensembl	Ensembl	12,453 nt	Select Tool ZFIN BLAST
mRNA	ank3a-204 (1) Ensembl	Ensembl	523 nt	Select Tool
mRNA	ank3a-205 (1) Ensembl	Ensembl	5,850 nt	Select Tool
mRNA	ank3a-206 (1) Ensembl	Ensembl	540 nt	Select Tool
mRNA	ank3a-207 (1) Ensembl	Ensembl	795 nt	Select Tool
ncRNA	ank3a-004 (1) Ensembl	Ensembl	740 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations