Gene

tbx5b

ID

ZDB-GENE-060601-2

Name

T-box transcription factor 5b

Symbol

tbx5b Nomenclature History

Previous Names

si:dkey-114c15.2

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Description

Predicted to have DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II activating transcription factor binding activity; and RNA polymerase II regulatory region sequence-specific DNA binding activity. Involved in several processes, including embryonic heart tube morphogenesis; optic nerve development; and pectoral fin development. Predicted to localize to cytoplasm and nucleus. Human ortholog(s) of this gene implicated in Holt-Oram syndrome. Is expressed in cardiovascular system; eye; immature eye; lateral plate mesoderm; and pectoral fin. Orthologous to human TBX5 (T-box transcription factor 5).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from 4 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 16 figures from 5 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tbx5b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Holt-Oram syndrome	Alliance	Holt-Oram syndrome	142900

Associated With tbx5b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018186	Transcription factor, T-box, conserved site
Domain	IPR046360	T-box transcription factor, DNA-binding domain
Family	IPR001699	T-box transcription factor
Homologous_superfamily	IPR008967	p53-like transcription factor, DNA-binding domain superfamily
Homologous_superfamily	IPR036960	T-box superfamily