Gene
tbx5b
- ID
- ZDB-GENE-060601-2
- Name
- T-box transcription factor 5b
- Symbol
- tbx5b Nomenclature History
- Previous Names
-
- si:dkey-114c15.2
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including embryonic heart tube morphogenesis; optic nerve development; and pectoral fin development. Predicted to be located in nucleus. Is expressed in several structures, including cardiovascular system; eye; fin bud; immature eye; and lateral plate mesoderm. Human ortholog(s) of this gene implicated in Holt-Oram syndrome. Orthologous to human TBX5 (T-box transcription factor 5).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 16 figures from 5 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ch3 | Allele with one insertion | Intron 1 | Splice Site, Intron Gain of Intron 1, Frameshift, Premature Stop | CRISPR |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Holt-Oram syndrome | Alliance | Holt-Oram syndrome | 142900 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018186 | Transcription factor, T-box, conserved site |
| Domain | IPR046360 | T-box transcription factor, DNA-binding domain |
| Family | IPR001699 | T-box transcription factor |
| Homologous_superfamily | IPR008967 | p53-like transcription factor, DNA-binding domain superfamily |
| Homologous_superfamily | IPR036960 | T-box superfamily |
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Domain Details Per Protein
| Protein | Length | p53-like transcription factor, DNA-binding domain superfamily | T-box superfamily | T-box transcription factor | T-box transcription factor, DNA-binding domain | Transcription factor, T-box, conserved site |
|---|---|---|---|---|---|---|
|
UniProtKB:E3W6T6
|
422 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-114C15 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001198771 (1) | 1353 nt | ||
| Genomic | GenBank:BX640539 (1) | 86752 nt | ||
| Polypeptide | UniProtKB:E3W6T6 (1) | 422 aa |
- Jones, A.A., Willoner, T., Mishoe Hernandez, L., DeLaurier, A. (2023) Exposure to valproic acid (VPA) reproduces hdac1 loss of function phenotypes in zebrafish. microPublication. Biology. 2023:
- Song, Y., Chen, W., Zhu, B., Ge, W. (2022) Disruption of Epidermal Growth Factor Receptor but Not EGF Blocks Follicle Activation in Zebrafish Ovary. Frontiers in cell and developmental biology. 9:750888
- Boyle-Anderson, E.A.T, Mao, Q., Ho, R.K. (2021) Tbx5a and Tbx5b paralogues act in combination to control separate vectors of migration in the fin field of zebrafish. Developmental Biology. 481:201-214
- Zhao, G., Zhu, Y., Hu, J., Gao, M., Hong, Y. (2021) l-selenomethionine induces zebrafish embryo cardiovascular defects via down-regulating expression of lrp2b. Chemosphere. 290:133351
- Mu, X., Chen, X., Liu, J., Yuan, L., Wang, D., Qian, L., Qian, Y., Shen, G., Huang, Y., Li, X., Li, Y., Lin, X. (2020) A multi-omics approach reveals molecular mechanisms by which phthalates induce cardiac defects in zebrafish (Danio rerio). Environmental pollution (Barking, Essex : 1987). 265:113876
- Sutton, G., White, L.J., Ford, A.G.P., Shechonge, A., Day, J.J., Dasmahapatra, K.K., Pownall, M.E. (2020) Exploring the Expression of Cardiac Regulators in a Vertebrate Extremophile: The Cichlid Fish Oreochromis (Alcolapia) alcalica. Journal of developmental biology. 8(4):
- Wei, Y., Meng, Y., Huang, Y., Liu, Z., Zhong, K., Ma, J., Zhang, W., Li, Y., Lu, H. (2020) Development toxicity and cardiotoxicity in zebrafish from exposure to iprodione. Chemosphere. 263:127860
- Chen, W., Bian, C., You, X., Li, J., Ye, L., Wen, Z., Lv, Y., Zhang, X., Xu, J., Yang, S., Gu, R., Lin, X., Shi, Q. (2019) Genome Sequencing of the Japanese Eel (Anguilla japonica) for Comparative Genomic Studies on tbx4 and a tbx4 Gene Cluster in Teleost Fishes. Marine drugs. 17(7)
- Boyle Anderson, E.A.T., Ho, R.K. (2018) A transcriptomics analysis of the Tbx5 paralogues in zebrafish. PLoS One. 13:e0208766
- Steimle, J.D., Rankin, S.A., Slagle, C.E., Bekeny, J., Rydeen, A.B., Chan, S.S., Kweon, J., Yang, X.H., Ikegami, K., Nadadur, R.D., Rowton, M., Hoffmann, A.D., Lazarevic, S., Thomas, W., Boyle Anderson, E.A.T., Horb, M.E., Luna-Zurita, L., Ho, R.K., Kyba, M., Jensen, B., Zorn, A.M., Conlon, F.L., Moskowitz, I.P. (2018) Evolutionarily conserved Tbx5-Wnt2/2b pathway orchestrates cardiopulmonary development.. Proceedings of the National Academy of Sciences of the United States of America. 115(45):E10615-E10624
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