Gene

prkg2

ID

ZDB-GENE-060531-80

Name

protein kinase cGMP-dependent 2

Symbol

prkg2 Nomenclature History

Previous Names

si:dkey-18e17.2 (1)

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Description

Predicted to have ATP binding activity; cGMP binding activity; and cGMP-dependent protein kinase activity. Predicted to be involved in protein phosphorylation. Is expressed in integument; nervous system; and pleuroperitoneal region. Orthologous to human PRKG2 (protein kinase cGMP-dependent 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from Li et al., 2018

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With prkg2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
acromesomelic dysplasia-4	Alliance	Acromesomelic dysplasia 4	619636
		Spondylometaphyseal dysplasia, Pagnamenta type	619638

Associated With prkg2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008271	Serine/threonine-protein kinase, active site
Binding_site	IPR017441	Protein kinase, ATP binding site
Conserved_site	IPR018488	Cyclic nucleotide-binding, conserved site
Domain	IPR000595	Cyclic nucleotide-binding domain
Domain	IPR000719	Protein kinase domain
Domain	IPR000961	AGC-kinase, C-terminal
Domain	IPR035014	cGMP-dependent protein kinase, catalytic domain
Family	IPR002374	cGMP-dependent kinase
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily
Homologous_superfamily	IPR014710	RmlC-like jelly roll fold
Homologous_superfamily	IPR018490	Cyclic nucleotide-binding domain superfamily