Gene
lrrc8ab
- ID
- ZDB-GENE-060531-43
- Name
- leucine rich repeat containing 8 VRAC subunit Ab
- Symbol
- lrrc8ab Nomenclature History
- Previous Names
-
- si:ch211-236k19.7
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to be involved in ion transport. Predicted to localize to integral component of membrane and plasma membrane. Human ortholog(s) of this gene implicated in agammaglobulinemia and agammaglobulinemia 5. Orthologous to several human genes including LRRC8A (leucine rich repeat containing 8 VRAC subunit A).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- 1 figure from Tseng et al., 2020
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 4 figures from Tseng et al., 2020
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
agammaglobulinemia 5 | Alliance | ?Agammaglobulinemia 5 | 613506 |
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Length | Leucine-rich repeat | Leucine-rich repeat domain-containing protein | Leucine-rich repeat domain superfamily | Leucine-rich repeat, typical subtype | LRRC8, pannexin-like TM region |
---|---|---|---|---|---|---|
UniProtKB:A2BF98
|
796 |
Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
lrrc8ab-201
(1)
|
Ensembl | 7,828 nt | ||
mRNA |
lrrc8ab-202
(1)
|
Ensembl | 2,717 nt |
Interactions and Pathways
No data available
Plasmids
No data available