Gene

arhgef28a

ID

ZDB-GENE-060531-28

Name

Rho guanine nucleotide exchange factor (GEF) 28a

Symbol

arhgef28a Nomenclature History

Previous Names

arhgef28 (1)
rgnef (1)
p190RhoGEF (1)
si:ch211-1o14.5 (1)

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Description

Predicted to have guanyl-nucleotide exchange factor activity and metal ion binding activity. Involved in Golgi organization; cell-matrix adhesion; and muscle tissue morphogenesis. Is expressed in ball; head; notochord; somite; and trunk. Orthologous to human ARHGEF28 (Rho guanine nucleotide exchange factor 28).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 4 figures from Cao et al., 2016
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With arhgef28a Human Ortholog

No data available

Associated With arhgef28a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000219	Dbl homology (DH) domain
Domain	IPR001849	Pleckstrin homology domain
Domain	IPR002219	Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
Domain	IPR037819	ARHGEF28, PH domain
Domain	IPR041020	ARHGEF1-like, PH domain
Family	IPR051632	Rho guanine nucleotide exchange factor
Homologous_superfamily	IPR011993	PH-like domain superfamily
Homologous_superfamily	IPR035899	Dbl homology (DH) domain superfamily
Homologous_superfamily	IPR046349	C1-like domain superfamily

Domain Details Per Protein

Protein	Length	ARHGEF1-like, PH domain	ARHGEF28, PH domain	C1-like domain superfamily	Dbl homology (DH) domain	Dbl homology (DH) domain superfamily	PH-like domain superfamily	Pleckstrin homology domain	Protein kinase C-like, phorbol ester/diacylglycerol-binding domain	Rho guanine nucleotide exchange factor
UniProtKB:F6P6M2 InterPro	1753
UniProtKB:A0A8M9PYS9 InterPro	1782
UniProtKB:A0A8M9QEQ4 InterPro	1441
UniProtKB:A0A8M3ASG5 InterPro	1810
UniProtKB:A0A8M6YZA7 InterPro	1783
UniProtKB:A0A8M9Q483 InterPro	1816
UniProtKB:A0A8M6Z0T3 InterPro	1754
UniProtKB:A0A8M9PL62 InterPro	1787
UniProtKB:A0A8M6YYE7 InterPro	1817
UniProtKB:A0A8M9QEQ0 InterPro	1809
UniProtKB:A0A8M6Z734 InterPro	1442
UniProtKB:A0A8M6Z6H3 InterPro	1788

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	arhgef28-202 (1) Ensembl	Ensembl	6,200 nt	Select Tool
mRNA	arhgef28a-201 (1) Ensembl	Ensembl	6,091 nt	Select Tool ZFIN BLAST
mRNA	arhgef28a-203 (1) Ensembl	Ensembl	4,803 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations