Gene
nr3c2
- ID
- ZDB-GENE-060531-23
- Name
- nuclear receptor subfamily 3, group C, member 2
- Symbol
- nr3c2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Enables nuclear steroid receptor activity and steroid hormone binding activity. Acts upstream of or within cellular response to cortisol stimulus; multicellular organismal response to stress; and positive regulation of glucocorticoid receptor signaling pathway. Predicted to be located in nucleus. Is expressed in several structures, including blood; heart; liver; male organism; and pleuroperitoneal region. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in autosomal dominant pseudohypoaldosteronism type 1 and pseudohypoaldosteronism. Orthologous to human NR3C2 (nuclear receptor subfamily 3 group C member 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 24 figures from 14 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- dq017617 (7 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ca402 | Allele with one delins | Exon 2 | Premature Stop | CRISPR | |
| ct867 | Allele with one deletion | Unknown | Frameshift, Premature Stop | CRISPR | |
| ia32 | Allele with one deletion | Exon 3 | Frameshift, Premature Stop | not specified | |
| inr11 | Allele with one deletion | Unknown | Frameshift, Premature Stop | CRISPR | |
| mn66 | Allele with one deletion | Exon 2 | Frameshift, Premature Stop | TALEN | |
| mn67 | Allele with one deletion | Exon 2 | Frameshift, Premature Stop | TALEN | |
| sa13656 | Allele with one point mutation | Unknown | Splice Site | ENU |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant pseudohypoaldosteronism type 1 | Alliance | Pseudohypoaldosteronism type I, autosomal dominant | 177735 |
| Hypertension, early-onset, autosomal dominant, with exacerbation in pregnancy | 605115 |
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| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| autism spectrum disorder | nr3c2ct867/ct867 (AB/TL) | standard conditions | Ruzzo et al., 2019 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000536 | Nuclear hormone receptor, ligand-binding domain |
| Domain | IPR001628 | Zinc finger, nuclear hormone receptor-type |
| Family | IPR001723 | Nuclear hormone receptor |
| Family | IPR050200 | Nuclear hormone receptor family NR3 subfamily |
| Homologous_superfamily | IPR013088 | Zinc finger, NHR/GATA-type |
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Domain Details Per Protein
| Protein | Length | Nuclear hormone receptor | Nuclear hormone receptor family NR3 subfamily | Nuclear hormone receptor, ligand-binding domain | Nuclear hormone receptor-like domain superfamily | Zinc finger, NHR/GATA-type | Zinc finger, nuclear hormone receptor-type |
|---|---|---|---|---|---|---|---|
|
UniProtKB:A6YIH7
|
970 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-273B10 | ZFIN Curated Data | |
| Contained in | BAC | CH211-189L17 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-38N1 | ZFIN Curated Data | |
| Contained in | BAC | DKEYP-14G8 | ZFIN Curated Data | |
| Encodes | EST | dq017617 | Bertrand et al., 2007 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001100403 (1) | 3540 nt | ||
| Genomic | GenBank:CR388021 (1) | 150805 nt | ||
| Polypeptide | UniProtKB:A6YIH7 (1) | 970 aa |
- Chin, J.S.R., Phan, T.N., Albert, L.T., Keene, A.C., Duboué, E.R. (2022) Long lasting anxiety following early life stress is dependent on glucocorticoid signaling in zebrafish. Scientific Reports. 12:12826
- Dinarello, A., Tesoriere, A., Martini, P., Fontana, C.M., Volpato, D., Badenetti, L., Terrin, F., Facchinello, N., Romualdi, C., Carnevali, O., Dalla Valle, L., Argenton, F. (2022) Zebrafish Mutant Lines Reveal the Interplay between nr3c1 and nr3c2 in the GC-Dependent Regulation of Gene Transcription. International Journal of Molecular Sciences. 23(5):
- Faught, E., Vijayan, M.M. (2022) The mineralocorticoid receptor functions as a key glucose regulator in the skeletal muscle of zebrafish. Endocrinology. 163(11):
- Morgan, R., Andreassen, A.H., Åsheim, E.R., Finnøen, M.H., Dresler, G., Brembu, T., Loh, A., Miest, J.J., Jutfelt, F. (2022) Reduced physiological plasticity in a fish adapted to stable temperatures. Proceedings of the National Academy of Sciences of the United States of America. 119:e2201919119
- Nipu, N., Antomagesh, F., Faught, E., Vijayan, M.M. (2022) Glucocorticoid receptor activation reduces food intake independent of hyperglycemia in zebrafish. Scientific Reports. 12:15677
- Sun, F., Ou, J., Shoffner, A.R., Luan, Y., Yang, H., Song, L., Safi, A., Cao, J., Yue, F., Crawford, G.E., Poss, K.D. (2022) Enhancer selection dictates gene expression responses in remote organs during tissue regeneration. Nature cell biology. 24(5):685-696
- Evans, J.R., Torres-Pérez, J.V., Miletto Petrazzini, M.E., Riley, R., Brennan, C.H. (2021) Stress reactivity elicits a tissue-specific reduction in telomere length in aging zebrafish (Danio rerio). Scientific Reports. 11:339
- Faught, E., Vijayan, M.M. (2021) Coordinated action of CRH and cortisol shapes acute stress-induced behavioural response in zebrafish. Neuroendocrinology. 112(1):74-87
- Ikeda, A., Komamizu, M., Hayashi, A., Yamasaki, C., Okada, K., Kawabe, M., Komatsu, M., Shiozaki, K. (2021) Neu1 deficiency induces abnormal emotional behavior in zebrafish. Scientific Reports. 11:13477
- Kawabe, M., Hayashi, A., Komatsu, M., Inui, A., Shiozaki, K. (2021) Ninjinyoeito improves anxiety behavior in neuropeptide Y deficient zebrafish. Neuropeptides. 87:102136
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