Gene

dab1a

ID

ZDB-GENE-060528-1

Name

DAB adaptor protein 1a

Symbol

dab1a Nomenclature History

Previous Names

dab1
si:dkey-242m13.1

Type

protein_coding_gene

Location

Chr: 20 Mapping Details/Browsers

Description

Predicted to be involved in lateral motor column neuron migration and ventral spinal cord development. Predicted to localize to cytoplasm. Human ortholog(s) of this gene implicated in spinocerebellar ataxia type 37. Is expressed in several structures, including brain; immature eye; pronephric duct; retina; and spinal cord interneuron. Orthologous to human DAB1 (DAB adaptor protein 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

10 figures from 4 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 5 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With dab1a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
spinocerebellar ataxia type 37	Alliance	Spinocerebellar ataxia 37	615945

Associated With dab1a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR048559	Disabled homolog 1/2, sulfatide-binding motif
Domain	IPR006020	PTB/PI domain
Domain	IPR048561	Disabled, phosphotyrosine-binding domain
Homologous_superfamily	IPR011993	PH-like domain superfamily

Domain Details Per Protein

Protein	Length	Disabled homolog 1/2, sulfatide-binding motif	Disabled, phosphotyrosine-binding domain	PH-like domain superfamily	PTB/PI domain
UniProtKB:A0A8M3AKN7 InterPro	571
UniProtKB:A0A8M3AW18 InterPro	597
UniProtKB:A0A8M2BHH7 InterPro	576
UniProtKB:F1Q6J4 InterPro	565
UniProtKB:A2BEF7 InterPro	537
UniProtKB:A0A8M3B3Y8 InterPro	563
UniProtKB:Q1PSH4 InterPro	588
UniProtKB:A0A0R4IQY1 InterPro	586

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	dab1a-201 (1) Ensembl	Ensembl	1,632 nt	Select Tool ZFIN BLAST
mRNA	dab1a-202 (1) Ensembl	Ensembl	1,962 nt	Select Tool ZFIN BLAST
mRNA	dab1a-205 (1) Ensembl	Ensembl	2,535 nt	Select Tool
mRNA	dab1a-206 (1) Ensembl	Ensembl	1,949 nt	Select Tool ZFIN BLAST
mRNA	dab1a-207 (1) Ensembl	Ensembl	1,714 nt	Select Tool ZFIN BLAST
mRNA	dab1a-208 (1) Ensembl	Ensembl	2,168 nt	Select Tool ZFIN BLAST
ncRNA	dab1a-002 (1) Ensembl	Ensembl	2,680 nt	Select Tool
ncRNA	dab1a-004 (1) Ensembl	Ensembl	2,168 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations