Gene

git2a

ID

ZDB-GENE-060526-267

Name

G protein-coupled receptor kinase interacting ArfGAP 2a

Symbol

git2a Nomenclature History

Previous Names

git2
si:dkey-234h16.4

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Description

Predicted to enable GTPase activator activity and small GTPase binding activity. Acts upstream of or within cell migration involved in gastrulation and regulation of cell morphogenesis. Predicted to be active in synapse. Orthologous to human GIT2 (GIT ArfGAP 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Yu et al., 2011

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 5 figures from Yu et al., 2011
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With git2a Human Ortholog

No data available

Associated With git2a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001164	Arf GTPase activating protein
Domain	IPR013724	GIT, Spa2 homology (SHD) domain
Domain	IPR022018	ARF GTPase-activating protein GIT1, C-terminal
Domain	IPR032352	Arf GTPase-activating protein GIT1/2, coiled-coil domain
Family	IPR047161	ARF GTPase-activating protein Git-like
Homologous_superfamily	IPR036770	Ankyrin repeat-containing domain superfamily
Homologous_superfamily	IPR037278	ARFGAP/RecO-like zinc finger
Homologous_superfamily	IPR038508	ArfGAP domain superfamily
Repeat	IPR002110	Ankyrin repeat

Domain Details Per Protein

Protein	Length	Ankyrin repeat	Ankyrin repeat-containing domain superfamily	ArfGAP domain superfamily	ARFGAP/RecO-like zinc finger	Arf GTPase activating protein	Arf GTPase-activating protein GIT1/2, coiled-coil domain	ARF GTPase-activating protein GIT1, C-terminal	ARF GTPase-activating protein Git-like	GIT, Spa2 homology (SHD) domain
UniProtKB:A0A8M9Q912 InterPro	432
UniProtKB:A0A8M2BCD7 InterPro	804
UniProtKB:A0A8M2BCH9 InterPro	802
UniProtKB:A0A8M3ASB4 InterPro	752
UniProtKB:A2BG45 InterPro	750
UniProtKB:A0A8M9QEB8 InterPro	746
UniProtKB:A0A8M3B2D0 InterPro	710