Gene

kank1b

ID

ZDB-GENE-060526-260

Name

KN motif and ankyrin repeat domains 1b

Symbol

kank1b Nomenclature History

Previous Names

si:dkey-226m8.9 (1)

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Description

Predicted to have oxidoreductase activity. Predicted to be involved in negative regulation of actin filament polymerization. Predicted to localize to cytoplasm and cytoskeleton. Human ortholog(s) of this gene implicated in spastic quadriplegia. Is expressed in central nervous system; eye; hindbrain; and midbrain. Orthologous to human KANK1 (KN motif and ankyrin repeat domains 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Hensley et al., 2016

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With kank1b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
spastic quadriplegic cerebral palsy 2	Alliance	Cerebral palsy, spastic quadriplegic, 2	612900

Associated With kank1b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR021939	Kank N-terminal motif
Family	IPR047184	KN motif and ankyrin repeat domain-containing protein 1-4
Homologous_superfamily	IPR011254	Prismane-like superfamily
Homologous_superfamily	IPR036770	Ankyrin repeat-containing domain superfamily
Repeat	IPR002110	Ankyrin repeat

Domain Details Per Protein

Protein	Length	Ankyrin repeat	Ankyrin repeat-containing domain superfamily	Kank N-terminal motif	KN motif and ankyrin repeat domain-containing protein 1-4	Prismane-like superfamily
UniProtKB:A5WUM1 InterPro	1054
UniProtKB:A0A8M2BJ97 InterPro	1170
UniProtKB:A0A8M9PXR2 InterPro	1009

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	kank1b-201 (1) Ensembl	Ensembl	3,907 nt	Select Tool ZFIN BLAST
mRNA	kank1b-203 (1) Ensembl	Ensembl	2,438 nt	Select Tool
mRNA	kank1b-204 (1) Ensembl	Ensembl	411 nt	Select Tool
ncRNA	kank1b-003 (1) Ensembl	Ensembl	535 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

Addgene:121979

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations