Gene
sftpbb
- ID
- ZDB-GENE-060526-155
- Name
- surfactant protein Bb
- Symbol
- sftpbb Nomenclature History
- Previous Names
-
- si:ch211-283h6.6
- wu:fd19f07
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable methyltransferase activity. Predicted to act upstream of or within methylation and sphingolipid metabolic process. Predicted to be located in lysosome and nucleus. Human ortholog(s) of this gene implicated in lung disease (multiple); respiratory syncytial virus infectious disease; and toxic shock syndrome. Orthologous to several human genes including MEPCE (methylphosphate capping enzyme).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| pulmonary alveolar proteinosis | Alliance | Surfactant metabolism dysfunction, pulmonary, 1 | 265120 |
1 - 1 of 1
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Saposin | Saposin B type domain | Saposin B type, region 2 | Saposin-like | Saposin-like type B, region 1 | Sphingolipid Activators and Surfactant Proteins | Zinc finger C2H2-type |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:B8JK19
|
317 |
1 - 1 of 1
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
sftpbb-201
(1)
|
Ensembl | 1,822 nt |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-173B16 | ZFIN Curated Data | |
| Contained in | BAC | CH211-283H6 | ZFIN Curated Data | |
| Encodes | EST | fd19f07 |
1 - 3 of 3
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001171066 (1) | 954 nt | ||
| Genomic | GenBank:BX537304 (1) | 157564 nt | ||
| Polypeptide | UniProtKB:B8JK19 (1) | 317 aa |
- Kuretani, A., Yamamoto, T., Taira, M., Michiue, T. (2021) Evolution of hes gene family in vertebrates: the hes5 cluster genes have specifically increased in frogs. BMC ecology and evolution. 21:147
- Wagner, K.D., Ying, Y., Leong, W., Jiang, J., Hu, X., Chen, Y., Michiels, J.F., Lu, Y., Gilson, E., Wagner, N., Ye, J. (2017) The differential spatiotemporal expression pattern of shelterin genes throughout lifespan. Aging. 9(4):1219-1232
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
1 - 4 of 4
Show