Gene

srgap3

ID

ZDB-GENE-060524-4

Name

SLIT-ROBO Rho GTPase activating protein 3

Symbol

srgap3 Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 6 Mapping Details/Browsers

Description

Predicted to have Rac GTPase binding activity. Predicted to be involved in negative regulation of cell migration. Predicted to localize to cytoplasm. Orthologous to human SRGAP3 (SLIT-ROBO Rho GTPase activating protein 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Zheng et al., 2022

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from van Dam et al., 2019
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With srgap3 Human Ortholog

No data available

Associated With srgap3 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000198	Rho GTPase-activating protein domain
Domain	IPR001060	FCH domain
Domain	IPR001452	SH3 domain
Domain	IPR031160	F-BAR domain
Domain	IPR035648	srGAP1/2/3, SH3 domain
Family	IPR051627	SLIT-ROBO Rho GTPase-activating
Homologous_superfamily	IPR008936	Rho GTPase activation protein
Homologous_superfamily	IPR027267	AH/BAR domain superfamily
Homologous_superfamily	IPR036028	SH3-like domain superfamily

Domain Details Per Protein

Protein	Length	AH/BAR domain superfamily	F-BAR domain	FCH domain	Rho GTPase-activating protein domain	Rho GTPase activation protein	SH3 domain	SH3-like domain superfamily	SLIT-ROBO Rho GTPase-activating	srGAP1/2/3, SH3 domain
UniProtKB:A0A0R4IAE2 InterPro	1094
UniProtKB:E7EYC8 InterPro	1070

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	srgap3-201 (1) Ensembl	Ensembl	5,100 nt	Select Tool
mRNA	srgap3-205 (1) Ensembl	Ensembl	4,197 nt	Select Tool ZFIN BLAST
ncRNA	srgap3-002 (1) Ensembl	Ensembl	881 nt	Select Tool
ncRNA	srgap3-003 (1) Ensembl	Ensembl	468 nt	Select Tool
ncRNA	srgap3-004 (1) Ensembl	Ensembl	539 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations