Gene
smyd1b
- ID
- ZDB-GENE-060522-1
- Name
- SET and MYND domain containing 1b
- Symbol
- smyd1b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Enables histone H3K4 methyltransferase activity and myosin binding activity. Acts upstream of or within several processes, including histone H3-K4 methylation; muscle cell development; and regulation of cardiac muscle fiber development. Located in M band. Is expressed in cardiovascular system; musculature system; segmental plate; somite; and tail bud. Orthologous to human SMYD1 (SET and MYND domain containing 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 22 figures from 14 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 33 figures from 12 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| b212 | unknown | Unknown | Unknown | ENU | |
| sa15678 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa34269 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| tm123a | Allele with one insertion | Intron 1 | Splice Site, Premature Stop | ENU | |
| to241a | unknown | Unknown | Unknown | ENU | |
| zf340 | Allele with one point mutation | Exon 2 | Premature Stop | ENU |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Histone-lysine N-methyltransferase | SET domain | SET domain superfamily | SMYD1, SET domain | Tetratricopeptide-like helical domain superfamily | Zinc finger, MYND-type |
|---|---|---|---|---|---|---|---|
|
UniProtKB:Q2MJQ9
|
486 | ||||||
|
UniProtKB:Q2MJQ8
|
473 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
smyd1b-201
(1)
|
Ensembl | 1,422 nt | ||
| mRNA |
smyd1b-202
(1)
|
Ensembl | 1,819 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-368O6 | ZFIN Curated Data | |
| Contained in | BAC | CH211-14C17 | ZFIN Curated Data | |
| Contained in | Fosmid | ZFOS-335G10 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194837 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001039636 (1) | 1461 nt | ||
| Genomic | GenBank:CT027631 | 194262 nt | ||
| Polypeptide | UniProtKB:Q2MJQ9 (1) | 486 aa |
- Livne, H., Avital, T., Ruppo, S., Harazi, A., Mitrani-Rosenbaum, S., Daya, A. (2022) Generation and characterization of a novel gne Knockout Model in Zebrafish. Frontiers in cell and developmental biology. 10:976111
- Jiao, S., Xu, R., Du, S. (2021) Smyd1 is essential for myosin expression and sarcomere organization in craniofacial, extraocular, and cardiac muscles. Journal of genetics and genomics = Yi chuan xue bao. 48(3):208-218
- Jin, X., Liu, W., Miao, J., Tai, Z., Li, L., Guan, P., Liu, J.X. (2021) Copper ions impair zebrafish skeletal myofibrillogenesis via epigenetic regulation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 35:e21686
- Xu, R., Du, S. (2021) Overexpression of Lifeact-GFP Disrupts F-Actin Organization in Cardiomyocytes and Impairs Cardiac Function. Frontiers in cell and developmental biology. 9:746818
- Han, C.R., Wang, H., Hoffmann, V., Zerfas, P., Kruhlak, M., Cheng, S.Y. (2020) Thyroid hormone receptor α mutations cause heart defects in zebrafish. Thyroid : official journal of the American Thyroid Association. 31(2):315-326
- She, P., Zhang, H., Peng, X., Sun, J., Gao, B., Zhou, Y., Zhu, X., Hu, X., Lai, K.S., Wong, J., Zhou, B., Wang, L., Zhong, T.P. (2020) The Gridlock transcriptional repressor impedes vertebrate heart regeneration by restricting expression of lysine methyltransferase. Development (Cambridge, England). 147(18):
- Shi, Y., Li, Y., Wang, Y., Zhu, P., Chen, Y., Wang, H., Yue, S., Xia, X., Chen, J., Jiang, Z., Zhou, C., Cai, W., Yuan, H., Wu, Y., Wan, Y., Li, X., Zhu, X., Zhou, Z., Dai, G., Li, F., Mo, X., Ye, X., Fan, X., Zhuang, J., Wu, X., Yuan, W. (2020) BVES downregulation in non-syndromic tetralogy of fallot is associated with ventricular outflow tract stenosis. Scientific Reports. 10:14167
- Cai, M., Han, L., Liu, L., He, F., Chu, W., Zhang, J., Tian, Z., Du, S. (2019) Defective sarcomere assembly in smyd1a and smyd1b zebrafish mutants. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33(5):6209-6225
- Healy, T.M., Schulte, P.M. (2019) Patterns of alternative splicing in response to cold acclimation in fish. The Journal of experimental biology. 222(Pt 5):
- Li, B., Li, S., He, Q., Du, S. (2019) Generation of MuRF-GFP transgenic zebrafish models for investigating murf gene expression and protein localization in Smyd1b and Hsp90α1 knockdown embryos. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. 240:110368
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