Gene

usp22

ID

ZDB-GENE-060512-211

Name

ubiquitin specific peptidase 22

Symbol

usp22 Nomenclature History

Previous Names

zgc:136342

Type

protein_coding_gene

Location

Chr: 12 Mapping Details/Browsers

Description

Predicted to have thiol-dependent ubiquitinyl hydrolase activity and zinc ion binding activity. Predicted to be involved in chromatin organization; protein deubiquitination; and ubiquitin-dependent protein catabolic process. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability. Orthologous to several human genes including USP22 (ubiquitin specific peptidase 22).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Tse et al., 2009
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With usp22 Human Ortholog

No data available

Associated With usp22 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018200	Ubiquitin specific protease, conserved site
Domain	IPR001394	Peptidase C19, ubiquitin carboxyl-terminal hydrolase
Domain	IPR001607	Zinc finger, UBP-type
Domain	IPR028889	Ubiquitin specific protease domain
Family	IPR050185	Ubiquitin carboxyl-terminal hydrolase
Homologous_superfamily	IPR013083	Zinc finger, RING/FYVE/PHD-type
Homologous_superfamily	IPR038765	Papain-like cysteine peptidase superfamily

Domain Details Per Protein

Protein	Length	Papain-like cysteine peptidase superfamily	Peptidase C19, ubiquitin carboxyl-terminal hydrolase	Ubiquitin carboxyl-terminal hydrolase	Ubiquitin specific protease, conserved site	Ubiquitin specific protease domain	Zinc finger, RING/FYVE/PHD-type	Zinc finger, UBP-type
UniProtKB:A0A8M9QEE8 InterPro	507
UniProtKB:A0A8M9QMM5 InterPro	506
UniProtKB:A6H8I0 InterPro	506

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	usp22-201 (1) Ensembl	Ensembl	3,430 nt	Select Tool ZFIN BLAST
mRNA	usp22-202 (1) Ensembl	Ensembl	3,418 nt	Select Tool
mRNA	usp22-203 (1) Ensembl	Ensembl	1,994 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations