Gene
fanca
- ID
- ZDB-GENE-060508-1
- Name
- FA complementation group A
- Symbol
- fanca Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to be involved in interstrand cross-link repair. Predicted to localize to Fanconi anaemia nuclear complex and integral component of membrane. Human ortholog(s) of this gene implicated in several diseases, including Fanconi anemia (multiple); acute myeloid leukemia; esophagus squamous cell carcinoma; ovarian disease (multiple); and skin melanoma. Is expressed in several structures, including brain; eye; gonad; gut; and tail bud. Orthologous to human FANCA (FA complementation group A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from Titus et al., 2009
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Fanconi anemia complementation group A | Alliance | Fanconi anemia, complementation group A | 227650 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| Fanconi anemia | fancahg41/hg41 (NHGRI-1) | standard conditions | Raman et al., 2021 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Fanconi anaemia group A protein | Fanconi anaemia group A protein, N-terminal domain |
|---|---|---|---|
|
UniProtKB:Q1X874
|
1375 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available