Gene
fndc5b
- ID
- ZDB-GENE-060503-916
- Name
- fibronectin type III domain containing 5b
- Symbol
- fndc5b Nomenclature History
- Previous Names
-
- si:dkey-264p5.1
- zgc:158684
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to enable hormone activity. Predicted to be located in extracellular region; peroxisomal membrane; and plasma membrane. Is expressed in heart and muscle. Orthologous to human FNDC5 (fibronectin type III domain containing 5).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Sundarrajan et al., 2017
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Length | Fibronectin type III | Fibronectin type III domain-containing protein 5, C-terminal domain | Fibronectin type III superfamily | Immunoglobulin-like fold |
---|---|---|---|---|---|
UniProtKB:A1L276
|
|||||
UniProtKB:Q1L867
|
207 | ||||
UniProtKB:A0A8M2B6C8
|
137 | ||||
UniProtKB:B7ZVM3
|
207 | ||||
UniProtKB:A0A8M9PNB5
|
173 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
fndc5b-201
(1)
|
Ensembl | 884 nt | ||
mRNA |
fndc5b-202
(1)
|
Ensembl | 1,394 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-264P5 | ZFIN Curated Data | |
Encodes | cDNA | MGC:158684 | ZFIN Curated Data | |
Encodes | cDNA | MGC:198363 | ZFIN Curated Data | |
Encodes | cDNA | MGC:198367 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001044337 (1) | 11241 nt | ||
Genomic | GenBank:CR954168 (1) | 128597 nt | ||
Polypeptide | UniProtKB:B7ZVM3 (1) | 207 aa |
- Kamoshita, M., Kumar, R., Anteghini, M., Kunze, M., Islinger, M., Martins Dos Santos, V., Schrader, M. (2022) Insights Into the Peroxisomal Protein Inventory of Zebrafish. Frontiers in Physiology. 13:822509
- Shoenhard, H., Jain, R.A., Granato, M. (2022) The calcium-sensing receptor (CaSR) regulates zebrafish sensorimotor decision making via a genetically defined cluster of hindbrain neurons. Cell Reports. 41:111790111790
- Sundarrajan, L., Jayakumar Rajeswari, J., Weber, L.P., Unniappan, S. (2021) Nesfatin-1-Like Peptide is a Negative Regulator of Cardiovascular Functions in Zebrafish and Goldfish. General and comparative endocrinology. 313:113892
- Sundarrajan, L., Rajeswari, J.J., Weber, L.P., Unniappan, S. (2021) The sympathetic/beta-adrenergic pathway mediates irisin regulation of cardiac functions in zebrafish. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. 259:111016
- Marquart, G.D., Tabor, K.M., Bergeron, S.A., Briggman, K.L., Burgess, H.A. (2019) Prepontine non-giant neurons drive flexible escape behavior in zebrafish. PLoS Biology. 17:e3000480
- Wang, S., Yang, Q., Wang, Z., Feng, S., Li, H., Ji, D., Zhang, S. (2018) Evolutionary and Expression Analyses Show Co-option of khdrbs Genes for Origin of Vertebrate Brain.. Frontiers in genetics. 8:225
- Sundarrajan, L., Unniappan, S. (2017) Small Interfering RNA Mediated Knockdown of Irisin Suppresses Food Intake and Modulates Appetite Regulatory Peptides in Zebrafish. General and comparative endocrinology. 252:200-208
- Sundarrajan, L., Yeung, C., Hahn, L., Weber, L.P., Unniappan, S. (2017) Irisin regulates cardiac physiology in zebrafish. PLoS One. 12:e0181461
- Li, X., Fang, W., Hu, Y., Wang, Y., Li, J. (2015) Characterization of fibronectin type III domain-containing protein 5 (FNDC5) gene in chickens: cloning, tissue expression, and regulation of its expression in the muscle by fasting and cold exposure. Gene. 570(2):221-9
- Marquart, G.D., Tabor, K.M., Brown, M., Strykowski, J.L., Varshney, G.K., LaFave, M.C., Mueller, T., Burgess, S.M., Higashijima, S., Burgess, H.A. (2015) A 3D Searchable Database of Transgenic Zebrafish Gal4 and Cre Lines for Functional Neuroanatomy Studies. Frontiers in neural circuits. 9:78
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