Gene

vars2

ID

ZDB-GENE-060503-575

Name

valyl-tRNA synthetase 2, mitochondrial

Symbol

vars2 Nomenclature History

Previous Names

si:ch211-152p11.2

Type

protein_coding_gene

Location

Chr: 19 Mapping Details/Browsers

Description

Predicted to have valine-tRNA ligase activity. Predicted to be involved in valyl-tRNA aminoacylation. Predicted to localize to cytosol. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 20. Orthologous to human VARS2 (valyl-tRNA synthetase 2, mitochondrial).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Kayvanpour et al., 2022
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With vars2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
combined oxidative phosphorylation deficiency 20	Alliance	Combined oxidative phosphorylation deficiency 20	615917

Associated With vars2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR001412	Aminoacyl-tRNA synthetase, class I, conserved site
Domain	IPR002300	Aminoacyl-tRNA synthetase, class Ia
Domain	IPR013155	Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding
Domain	IPR033705	Valyl tRNA synthetase, anticodon-binding domain
Family	IPR002303	Valine-tRNA ligase
Homologous_superfamily	IPR009008	Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain
Homologous_superfamily	IPR009080	Aminoacyl-tRNA synthetase, class Ia, anticodon-binding
Homologous_superfamily	IPR014729	Rossmann-like alpha/beta/alpha sandwich fold