Gene

dyrk1b

ID

ZDB-GENE-060503-499

Name

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B

Symbol

dyrk1b Nomenclature History

Previous Names

si:ch211-225p5.1

Type

protein_coding_gene

Location

Chr: 16 Mapping Details/Browsers

Description

Predicted to have protein serine/threonine kinase activity and transcription coactivator activity. Involved in endoderm formation. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in abdominal obesity-metabolic syndrome 3. Is expressed in head and somite. Orthologous to human DYRK1B (dual specificity tyrosine phosphorylation regulated kinase 1B).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from Mazmanian et al., 2010

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 4 figures from Mazmanian et al., 2010
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With dyrk1b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
abdominal obesity-metabolic syndrome 3	Alliance	Abdominal obesity-metabolic syndrome 3	615812

Associated With dyrk1b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008271	Serine/threonine-protein kinase, active site
Binding_site	IPR017441	Protein kinase, ATP binding site
Domain	IPR000719	Protein kinase domain
Domain	IPR044131	Dual specificity tyrosine-phosphorylation-regulated kinase 1A/1B, catalytic domain
Family	IPR050494	Serine/threonine and dual-specificity kinase
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily

Domain Details Per Protein

Protein	Length	Dual specificity tyrosine-phosphorylation-regulated kinase 1A/1B, catalytic domain	Protein kinase, ATP binding site	Protein kinase domain	Protein kinase-like domain superfamily	Serine/threonine and dual-specificity kinase	Serine/threonine-protein kinase, active site
UniProtKB:A0A8M2B4L1 InterPro	826
UniProtKB:A0A0R4II39 InterPro	681
UniProtKB:D1L3Y5 InterPro	751
UniProtKB:A0A8M2B533 InterPro	833
UniProtKB:A0A8M2B4K6 InterPro	758

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	dyrk1b-201 (1) Ensembl	Havana	4382 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	dyrk1b-203 (1) Ensembl	Ensembl	3933 nt	Select Tool ZFIN BLAST
ncRNA	dyrk1b-002 (1) Ensembl	Havana	918 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations