Gene
dyrk1b
- ID
- ZDB-GENE-060503-499
- Name
- dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B
- Symbol
- dyrk1b Nomenclature History
- Previous Names
-
- si:ch211-225p5.1
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to have protein serine/threonine kinase activity and transcription coactivator activity. Involved in endoderm formation. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in abdominal obesity-metabolic syndrome 3. Is expressed in head and somite. Orthologous to human DYRK1B (dual specificity tyrosine phosphorylation regulated kinase 1B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Mazmanian et al., 2010
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 4 figures from Mazmanian et al., 2010
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| abdominal obesity-metabolic syndrome 3 | Alliance | Abdominal obesity-metabolic syndrome 3 | 615812 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR044131 | Dual specificity tyrosine-phosphorylation-regulated kinase 1A/1B, catalytic domain |
| Family | IPR050494 | Serine/threonine and dual-specificity kinase |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
Domain Details Per Protein
| Protein | Length | Dual specificity tyrosine-phosphorylation-regulated kinase 1A/1B, catalytic domain | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine and dual-specificity kinase | Serine/threonine-protein kinase, active site |
|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M2B4L1
|
826 | ||||||
|
UniProtKB:A0A0R4II39
|
681 | ||||||
|
UniProtKB:D1L3Y5
|
751 | ||||||
|
UniProtKB:A0A8M2B533
|
833 | ||||||
|
UniProtKB:A0A8M2B4K6
|
758 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
dyrk1b-201
(1)
|
Ensembl | 4,382 nt | ||
| mRNA |
dyrk1b-203
(1)
|
Ensembl | 3,933 nt | ||
| ncRNA |
dyrk1b-002
(1)
|
Ensembl | 918 nt |
Interactions and Pathways
No data available
Plasmids