Gene

ptpn22

ID
ZDB-GENE-060503-458
Name
protein tyrosine phosphatase non-receptor type 22
Symbol
ptpn22 Nomenclature History
Previous Names
  • si:dkey-78k11.1
Type
protein_coding_gene
Location
Chr: 23 Mapping Details/Browsers
Description
Predicted to have protein tyrosine phosphatase activity. Predicted to be involved in peptidyl-tyrosine dephosphorylation. Predicted to localize to cytoplasm and nucleus. Human ortholog(s) of this gene implicated in several diseases, including Addison's disease; autoimmune hypersensitivity disease (multiple); diabetes mellitus (multiple); rheumatoid arthritis (multiple); and vasculitis (multiple). Orthologous to human PTPN22 (protein tyrosine phosphatase non-receptor type 22).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
2 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Ma et al., 2022
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ptpn22 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
rheumatoid arthritis Alliance {Rheumatoid arthritis, susceptibility to} 180300
systemic lupus erythematosus Alliance {Systemic lupus erythematosus susceptibility to} 152700
type 1 diabetes mellitus Alliance {Diabetes, type 1, susceptibility to} 222100
Associated With ptpn22 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR016130 Protein-tyrosine phosphatase, active site
Domain IPR000242 Tyrosine-specific protein phosphatase, PTPase domain
Domain IPR000387 Tyrosine-specific protein phosphatases domain
Domain IPR003595 Protein-tyrosine phosphatase, catalytic
Family IPR047170 Tyrosine-protein phosphatase non-receptor type 12/18/22
Homologous_superfamily IPR029021 Protein-tyrosine phosphatase-like
Domain Details Per Protein
Protein Length Protein-tyrosine phosphatase, active site Protein-tyrosine phosphatase, catalytic Protein-tyrosine phosphatase-like Tyrosine-protein phosphatase non-receptor type 12/18/22 Tyrosine-specific protein phosphatase, PTPase domain Tyrosine-specific protein phosphatases domain
UniProtKB:A0A8M2B909 886
UniProtKB:A5D6T3 887
UniProtKB:A0A8M2B913 882
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA ptpn22-201 (1) Ensembl 2,664 nt
mRNA ptpn22-202 (1) Ensembl 585 nt
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations