Gene
tm6sf2b
- ID
- ZDB-GENE-060503-338
- Name
- transmembrane 6 superfamily member 2b
- Symbol
- tm6sf2b Nomenclature History
- Previous Names
-
- tm6sf2
- si:dkey-19f23.3
- zgc:158825
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Involved in lipid homeostasis and regulation of response to endoplasmic reticulum stress. Predicted to localize to endoplasmic reticulum membrane and endoplasmic reticulum-Golgi intermediate compartment membrane. Used to study fatty liver disease. Is expressed in intestine; liver; and posterior intestine. Orthologous to several human genes including TM6SF2 (transmembrane 6 superfamily member 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from O'Hare et al., 2017
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 7 figures from O'Hare et al., 2017
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| steatotic liver disease | WT + MO1-tm6sf2b | standard conditions | O'Hare et al., 2017 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | EXPERA domain | Transmembrane 6 superfamily member 1/2 |
|---|---|---|---|
|
UniProtKB:A1L2E0
|
374 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
tm6sf2-202
(1)
|
Ensembl | 1,283 nt | ||
| mRNA |
tm6sf2-203
(1)
|
Ensembl | 5,595 nt | ||
| ncRNA |
tm6sf2-002
(1)
|
Ensembl | 852 nt |
Interactions and Pathways
No data available
Plasmids
No data available