Gene
trioa
- ID
- ZDB-GENE-060503-334
- Name
- trio Rho guanine nucleotide exchange factor a
- Symbol
- trioa Nomenclature History
- Previous Names
-
- si:ch211-13c6.1
- si:dkey-158b13.2
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to have ATP binding activity; Rho guanyl-nucleotide exchange factor activity; and protein serine/threonine kinase activity. Predicted to be involved in axon guidance; central nervous system development; and protein phosphorylation. Predicted to localize to cytoplasm. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability and autosomal dominant non-syndromic intellectual disability 44. Orthologous to human TRIO (trio Rho guanine nucleotide exchange factor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Klems et al., 2020
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant intellectual developmental disorder 44 | Alliance | Intellectual developmental disorder, autosomal dominant 44, with microcephaly | 617061 |
| Intellectual developmental disorder, autosomal dominant 63, with macrocephaly | 618825 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000219 | Dbl homology (DH) domain |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR001251 | CRAL-TRIO lipid binding domain |
| Domain | IPR001452 | SH3 domain |
| Domain | IPR001849 | Pleckstrin homology domain |
| Domain | IPR003598 | Immunoglobulin subtype 2 |
| Domain | IPR003599 | Immunoglobulin domain subtype |
| Domain | IPR007110 | Immunoglobulin-like domain |
| Domain | IPR013098 | Immunoglobulin I-set |
| Domain | IPR028570 | Kalirin/Triple functional domain protein, SH3 domain 1 |
| Domain | IPR047053 | Kalirin/Triple functional domain protein, SH3 domain 2 |
| Domain | IPR047054 | Kalirin/Triple functional domain protein, pleckstrin homology (PH) domain 1 |
| Family | IPR051336 | Rho GTPase-activating Guanine Nucleotide Exchange Factors |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR011993 | PH-like domain superfamily |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR035899 | Dbl homology (DH) domain superfamily |
| Homologous_superfamily | IPR036028 | SH3-like domain superfamily |
| Homologous_superfamily | IPR036179 | Immunoglobulin-like domain superfamily |
| Homologous_superfamily | IPR036865 | CRAL-TRIO lipid binding domain superfamily |
| Repeat | IPR002017 | Spectrin repeat |
| Repeat | IPR018159 | Spectrin/alpha-actinin |
Domain Details Per Protein
| Protein | Length | CRAL-TRIO lipid binding domain | CRAL-TRIO lipid binding domain superfamily | Dbl homology (DH) domain | Dbl homology (DH) domain superfamily | Immunoglobulin domain subtype | Immunoglobulin I-set | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Immunoglobulin subtype 2 | Kalirin/Triple functional domain protein, pleckstrin homology (PH) domain 1 | Kalirin/Triple functional domain protein, SH3 domain 1 | Kalirin/Triple functional domain protein, SH3 domain 2 | PH-like domain superfamily | Pleckstrin homology domain | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Rho GTPase-activating Guanine Nucleotide Exchange Factors | Serine/threonine-protein kinase, active site | SH3 domain | SH3-like domain superfamily | Spectrin/alpha-actinin | Spectrin repeat |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9PNC8
|
1932 | ||||||||||||||||||||||||
|
UniProtKB:A0A8M3ASV0
|
3083 | ||||||||||||||||||||||||
|
UniProtKB:A0A8M9PNC1
|
3114 | ||||||||||||||||||||||||
|
UniProtKB:A0A8M6Z2C9
|
1914 | ||||||||||||||||||||||||
|
UniProtKB:A0A8M9PGG0
|
2317 | ||||||||||||||||||||||||
|
UniProtKB:A0A8M9PRK6
|
3115 | ||||||||||||||||||||||||
|
UniProtKB:A0A8M9PRL6
|
1945 | ||||||||||||||||||||||||
|
UniProtKB:A0A8M9P1U8
|
3111 | ||||||||||||||||||||||||
|
UniProtKB:Q1LUA6
|
3028 | ||||||||||||||||||||||||
|
UniProtKB:F1Q551
|
3087 | ||||||||||||||||||||||||
|
UniProtKB:A0A8M9PAZ8
|
2402 |
Interactions and Pathways
No data available
Plasmids
No data available