Gene
trioa
- ID
- ZDB-GENE-060503-334
- Name
- trio Rho guanine nucleotide exchange factor a
- Symbol
- trioa Nomenclature History
- Previous Names
-
- si:ch211-13c6.1
- si:dkey-158b13.2
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in axon guidance. Predicted to act upstream of or within central nervous system development and protein phosphorylation. Predicted to be active in cytoplasm. Predicted to be extrinsic component of membrane. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder and autosomal dominant intellectual developmental disorder 44. Orthologous to human TRIO (trio Rho guanine nucleotide exchange factor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Klems et al., 2020
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant intellectual developmental disorder 44 | Alliance | Intellectual developmental disorder, autosomal dominant 44, with microcephaly | 617061 |
| Intellectual developmental disorder, autosomal dominant 63, with macrocephaly | 618825 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000219 | Dbl homology (DH) domain |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR001251 | CRAL-TRIO lipid binding domain |
| Domain | IPR001452 | SH3 domain |
| Domain | IPR001849 | Pleckstrin homology domain |
| Domain | IPR003598 | Immunoglobulin subtype 2 |
| Domain | IPR003599 | Immunoglobulin domain subtype |
| Domain | IPR007110 | Immunoglobulin-like domain |
| Domain | IPR013098 | Immunoglobulin I-set |
| Domain | IPR028570 | Kalirin/Triple functional domain protein, SH3 domain 1 |
| Domain | IPR047053 | Kalirin/Triple functional domain protein, SH3 domain 2 |
| Domain | IPR047054 | Kalirin/Triple functional domain protein, pleckstrin homology (PH) domain 1 |
| Family | IPR051336 | Rho GTPase-activating Guanine Nucleotide Exchange Factors |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR011993 | PH-like domain superfamily |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR035899 | Dbl homology (DH) domain superfamily |
| Homologous_superfamily | IPR036028 | SH3-like domain superfamily |
| Homologous_superfamily | IPR036179 | Immunoglobulin-like domain superfamily |
| Homologous_superfamily | IPR036865 | CRAL-TRIO lipid binding domain superfamily |
| Repeat | IPR002017 | Spectrin repeat |
| Repeat | IPR018159 | Spectrin/alpha-actinin |
Domain Details Per Protein
| Protein | Length | CRAL-TRIO lipid binding domain | CRAL-TRIO lipid binding domain superfamily | Dbl homology (DH) domain | Dbl homology (DH) domain superfamily | Immunoglobulin domain subtype | Immunoglobulin I-set | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Immunoglobulin subtype 2 | Kalirin/Triple functional domain protein, pleckstrin homology (PH) domain 1 | Kalirin/Triple functional domain protein, SH3 domain 1 | Kalirin/Triple functional domain protein, SH3 domain 2 | PH-like domain superfamily | Pleckstrin homology domain | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Rho GTPase-activating Guanine Nucleotide Exchange Factors | Serine/threonine-protein kinase, active site | SH3 domain | SH3-like domain superfamily | Spectrin/alpha-actinin | Spectrin repeat |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9PNC8
|
1932 | ||||||||||||||||||||||||
|
UniProtKB:A0A8M3ASV0
|
3083 | ||||||||||||||||||||||||
|
UniProtKB:A0A8M9PNC1
|
3114 | ||||||||||||||||||||||||
|
UniProtKB:A0A8M6Z2C9
|
1914 | ||||||||||||||||||||||||
|
UniProtKB:A0A8M9PGG0
|
2317 | ||||||||||||||||||||||||
|
UniProtKB:A0A8M9PRK6
|
3115 | ||||||||||||||||||||||||
|
UniProtKB:A0A8M9PRL6
|
1945 | ||||||||||||||||||||||||
|
UniProtKB:A0A8M9P1U8
|
3111 | ||||||||||||||||||||||||
|
UniProtKB:Q1LUA6
|
3028 | ||||||||||||||||||||||||
|
UniProtKB:F1Q551
|
3087 | ||||||||||||||||||||||||
|
UniProtKB:A0A8M9PAZ8
|
2402 |
Interactions and Pathways
No data available
Plasmids
No data available