Gene

cacna1ia

ID

ZDB-GENE-060503-324

Name

calcium voltage-gated channel subunit alpha1 Ia

Symbol

cacna1ia Nomenclature History

Previous Names

cacna1i
si:ch211-51h13.1 (1)

Type

protein_coding_gene

Location

Chr: 3 Mapping Details/Browsers

Description

Predicted to enable low voltage-gated calcium channel activity and voltage-gated sodium channel activity. Predicted to be involved in several processes, including metal ion transport; neuronal action potential; and positive regulation of calcium ion-dependent exocytosis. Predicted to act upstream of or within calcium ion transmembrane transport and flagellated sperm motility. Predicted to be located in plasma membrane. Predicted to be part of voltage-gated sodium channel complex. Predicted to be active in neuron projection. Is expressed in atrium and cardiac ventricle. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human CACNA1I (calcium voltage-gated channel subunit alpha1 I).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 3 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Thyme et al., 2019
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With cacna1ia Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Neurodevelopmental disorder with speech impairment and with or without seizures	620114

Associated With cacna1ia Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR005821	Ion transport domain
Family	IPR005445	Voltage-dependent calcium channel, T-type, alpha-1 subunit
Family	IPR043203	Voltage-gated cation channel calcium and sodium
Homologous_superfamily	IPR027359	Voltage-dependent channel domain superfamily

Domain Details Per Protein

Protein	Length	Ion transport domain	Voltage-dependent calcium channel, T-type, alpha-1 subunit	Voltage-dependent channel domain superfamily	Voltage-gated cation channel calcium and sodium
UniProtKB:A0A2R8Q1A5 InterPro	2122
UniProtKB:A0A8M9PEP7 InterPro	2121

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	cacna1i-202 (1) Ensembl	Ensembl	7,247 nt	Select Tool ZFIN BLAST
mRNA	cacna1ia-201 (1) Ensembl	Ensembl	7,010 nt	Select Tool ZFIN BLAST
mRNA	cacna1ia-203 (1) Ensembl	Ensembl	7,148 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations