Gene
trit1
- ID
- ZDB-GENE-060503-297
- Name
- tRNA isopentenyltransferase 1
- Symbol
- trit1 Nomenclature History
- Previous Names
-
- si:ch211-194e15.1
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to enable tRNA dimethylallyltransferase activity. Predicted to be involved in tRNA modification. Predicted to act upstream of or within tRNA processing. Predicted to be located in cytoplasm. Predicted to be active in mitochondrion. Is expressed in telencephalon. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 35. Orthologous to human TRIT1 (tRNA isopentenyltransferase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7158183 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la013459Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la028038Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la028039Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa14214 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa23552 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa36863 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| combined oxidative phosphorylation deficiency 35 | Alliance | Combined oxidative phosphorylation deficiency 35 | 617873 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR022755 | Zinc finger, double-stranded RNA binding |
| Family | IPR018022 | IPP transferase |
| Family | IPR030666 | tRNA isopentenyltransferase, eukaryotes |
| Family | IPR039657 | Dimethylallyltransferase |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
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Domain Details Per Protein
| Protein | Length | Dimethylallyltransferase | IPP transferase | P-loop containing nucleoside triphosphate hydrolase | tRNA isopentenyltransferase, eukaryotes | Zinc finger C2H2 superfamily | Zinc finger, double-stranded RNA binding |
|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9PAY7
|
281 | ||||||
|
UniProtKB:Q1LWL7
|
447 | ||||||
|
UniProtKB:A0A8M9PRJ0
|
362 | ||||||
|
UniProtKB:A0A8M9PGE6
|
261 | ||||||
|
UniProtKB:A0A8M9PNA5
|
282 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-194E15 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:7158183 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:162802 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001044774 (1) | 2233 nt | ||
| Genomic | GenBank:BX547927 (1) | 215498 nt | ||
| Polypeptide | UniProtKB:Q1LWL7 (1) | 447 aa |
- Wang, S., Yang, Q., Wang, Z., Feng, S., Li, H., Ji, D., Zhang, S. (2018) Evolutionary and Expression Analyses Show Co-option of khdrbs Genes for Origin of Vertebrate Brain.. Frontiers in genetics. 8:225
- Diotel, N., Viales, R.R., Armant, O., März, M., Ferg, M., Rastegar, S., Strähle, U. (2015) Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches. The Journal of comparative neurology. 523(8):1202-21
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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