Gene

trit1

ID

ZDB-GENE-060503-297

Name

tRNA isopentenyltransferase 1

Symbol

trit1 Nomenclature History

Previous Names

si:ch211-194e15.1

Type

protein_coding_gene

Location

Chr: 19 Mapping Details/Browsers

Description

Predicted to enable tRNA dimethylallyltransferase activity. Predicted to be involved in tRNA modification. Predicted to act upstream of or within tRNA processing. Predicted to be located in cytoplasm. Predicted to be active in mitochondrion. Is expressed in telencephalon. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 35. Orthologous to human TRIT1 (tRNA isopentenyltransferase 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7158183 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With trit1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
combined oxidative phosphorylation deficiency 35	Alliance	Combined oxidative phosphorylation deficiency 35	617873

Associated With trit1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR022755	Zinc finger, double-stranded RNA binding
Family	IPR018022	IPP transferase
Family	IPR030666	tRNA isopentenyltransferase, eukaryotes
Family	IPR039657	Dimethylallyltransferase
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily	IPR036236	Zinc finger C2H2 superfamily

Domain Details Per Protein

Protein	Length	Dimethylallyltransferase	IPP transferase	P-loop containing nucleoside triphosphate hydrolase	tRNA isopentenyltransferase, eukaryotes	Zinc finger C2H2 superfamily	Zinc finger, double-stranded RNA binding
UniProtKB:A0A8M9PAY7 InterPro	281
UniProtKB:Q1LWL7 InterPro	447
UniProtKB:A0A8M9PRJ0 InterPro	362
UniProtKB:A0A8M9PGE6 InterPro	261
UniProtKB:A0A8M9PNA5 InterPro	282

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	trit1-201 (1) Ensembl	Ensembl	2,233 nt	Select Tool ZFIN BLAST
mRNA	trit1-202 (1) Ensembl	Ensembl	1,395 nt	Select Tool ZFIN BLAST
mRNA	trit1-203 (1) Ensembl	Ensembl	2,233 nt	Select Tool ZFIN BLAST
ncRNA	trit1-002 (1) Ensembl	Ensembl	780 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations