Gene
alg2
- ID
- ZDB-GENE-060502-2
- Name
- ALG2 alpha-1,3/1,6-mannosyltransferase
- Symbol
- alg2 Nomenclature History
- Previous Names
-
- im:7145131
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to have alpha-1,3-mannosyltransferase activity and glycolipid mannosyltransferase activity. Predicted to be involved in oligosaccharide-lipid intermediate biosynthetic process and protein glycosylation in endoplasmic reticulum. Localizes to nucleus. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Ii and congenital myasthenic syndrome 14. Orthologous to human ALG2 (ALG2 alpha-1,3/1,6-mannosyltransferase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from DeRossi et al., 2016
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| congenital disorder of glycosylation Ii | Alliance | Congenital disorder of glycosylation, type Ii | 607906 |
| congenital myasthenic syndrome 14 | Alliance | Myasthenic syndrome, congenital, 14, with tubular aggregates | 616228 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Glycosyl transferase, family 1 | Glycosyltransferase subfamily 4-like, N-terminal domain | Mannosyltransferase ALG2 |
|---|---|---|---|---|
|
UniProtKB:A0A8M1NFU6
|
402 | |||
|
UniProtKB:F1QPS1
|
455 |
Interactions and Pathways
No data available
Plasmids
No data available