Gene

pold1

ID
ZDB-GENE-060429-1
Name
polymerase (DNA directed), delta 1, catalytic subunit
Symbol
pold1 Nomenclature History
Previous Names
  • fla
  • flat head
  • im:7139126
  • zgc:152688
Type
protein_coding_gene
Location
Chr: 3 Mapping Details/Browsers
Description
Predicted to have 3'-5'-exodeoxyribonuclease activity and DNA-directed DNA polymerase activity. Involved in DNA replication. Predicted to localize to delta DNA polymerase complex. Is expressed in several structures, including brain; immature eye; neural crest; proliferative region; and retina. Orthologous to human POLD1 (DNA polymerase delta 1, catalytic subunit).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
14 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
12 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With pold1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Immunodeficiency 120 620836
Mandibular hypoplasia, deafness, progeroid features, and lipodystrophy syndrome 615381
{Colorectal cancer, susceptibility to, 10} 612591
Associated With pold1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR017964 DNA-directed DNA polymerase, family B, conserved site
Domain IPR006133 DNA-directed DNA polymerase, family B, exonuclease domain
Domain IPR006134 DNA-directed DNA polymerase, family B, multifunctional domain
Domain IPR025687 C4-type zinc-finger of DNA polymerase delta
Family IPR006172 DNA-directed DNA polymerase, family B
Family IPR050240 DNA polymerase type-B
Homologous_superfamily IPR012337 Ribonuclease H-like superfamily
Homologous_superfamily IPR023211 DNA polymerase, palm domain superfamily
Homologous_superfamily IPR036397 Ribonuclease H superfamily
Homologous_superfamily IPR042087 DNA polymerase family B, thumb domain
Homologous_superfamily IPR043502 DNA/RNA polymerase superfamily
Domain Details Per Protein
Protein Length C4-type zinc-finger of DNA polymerase delta DNA-directed DNA polymerase, family B DNA-directed DNA polymerase, family B, conserved site DNA-directed DNA polymerase, family B, exonuclease domain DNA-directed DNA polymerase, family B, multifunctional domain DNA polymerase family B, thumb domain DNA polymerase, palm domain superfamily DNA polymerase type-B DNA/RNA polymerase superfamily Ribonuclease H-like superfamily Ribonuclease H superfamily
UniProtKB:Q2KNE0
InterPro
1105
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA pold1-201 (1)
Ensembl
Ensembl 3,561 nt
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations
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