Gene

f9b

ID

ZDB-GENE-060421-7346

Name

coagulation factor IXb

Symbol

f9b Nomenclature History

Previous Names

zgc:136807

Type

protein_coding_gene

Location

Chr: 10 Mapping Details/Browsers

Description

Predicted to enable calcium ion binding activity and serine-type endopeptidase activity. Predicted to act upstream of or within blood coagulation and proteolysis. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in X-linked thrombophilia due to factor IX defect; X-linked warfarin sensitivity; and hemophilia B. Orthologous to human F9 (coagulation factor IX).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Iyer et al., 2021

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With f9b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
hemophilia B	Alliance	Hemophilia B	306900
X-linked thrombophilia due to factor IX defect	Alliance	Thrombophilia 8, X-linked, due to factor IX defect	300807
X-linked thrombophilia due to factor IX defect	Alliance	{Deep venous thrombosis, protection against}	300807
X-linked warfarin sensitivity	Alliance	{Warfarin sensitivity}	301052

Associated With f9b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR018114	Serine proteases, trypsin family, histidine active site
Active_site	IPR033116	Serine proteases, trypsin family, serine active site
Conserved_site	IPR018097	EGF-like calcium-binding, conserved site
Domain	IPR000294	Gamma-carboxyglutamic acid-rich (GLA) domain
Domain	IPR000742	EGF-like domain
Domain	IPR001254	Serine proteases, trypsin domain
Domain	IPR001881	EGF-like calcium-binding domain
Family	IPR001314	Peptidase S1A, chymotrypsin family
Family	IPR012224	Peptidase S1A, coagulation factor VII/IX/X/C/Z
Family	IPR050442	Peptidase S1 family, coagulation factors
Homologous_superfamily	IPR009003	Peptidase S1, PA clan
Homologous_superfamily	IPR017857	Coagulation factor-like, Gla domain superfamily
Homologous_superfamily	IPR035972	Gamma-carboxyglutamic acid-rich (GLA) domain superfamily
Homologous_superfamily	IPR043504	Peptidase S1, PA clan, chymotrypsin-like fold
PTM	IPR000152	EGF-type aspartate/asparagine hydroxylation site