Gene

nfixb

ID

ZDB-GENE-060421-5000

Name

nuclear factor I/Xb

Symbol

nfixb Nomenclature History

Previous Names

zgc:136878

Type

protein_coding_gene

Location

Chr: 3 Mapping Details/Browsers

Description

Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific. Predicted to be involved in negative regulation of transcription by RNA polymerase II and positive regulation of transcription by RNA polymerase II. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in Marshall-Smith syndrome and Sotos syndrome. Is expressed in midbrain; muscle; and telencephalon. Orthologous to human NFIX (nuclear factor I X).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With nfixb Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Marshall-Smith syndrome	Alliance	Marshall-Smith syndrome	602535
Sotos syndrome 2	Alliance	Malan syndrome	614753

Associated With nfixb Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR019739	CTF transcription factor/nuclear factor 1, conserved site
Domain	IPR003619	MAD homology 1, Dwarfin-type
Domain	IPR019548	CTF transcription factor/nuclear factor 1, N-terminal
Domain	IPR020604	CTF transcription factor/nuclear factor 1, DNA-binding domain
Family	IPR000647	CTF transcription factor/nuclear factor 1

Domain Details Per Protein

Protein	Length	CTF transcription factor/nuclear factor 1	CTF transcription factor/nuclear factor 1, conserved site	CTF transcription factor/nuclear factor 1, DNA-binding domain	CTF transcription factor/nuclear factor 1, N-terminal	MAD homology 1, Dwarfin-type
UniProtKB:A0A8M3B860 InterPro	562
UniProtKB:Q1RLS5 InterPro	440
UniProtKB:A0A8M2BAY5 InterPro	528
UniProtKB:A0A8M3AXV2 InterPro	530
UniProtKB:A0A8M3AQD9 InterPro	513
UniProtKB:A0A8M3AQR1 InterPro	556
UniProtKB:A0A8M2BBB5 InterPro	536
UniProtKB:A0A8M3AQR5 InterPro	561
UniProtKB:A0A8M3B0T9 InterPro	500
UniProtKB:A0A8M3B863 InterPro	512
UniProtKB:A0A8M3AXU6 InterPro	574
UniProtKB:A0A8M3AQD4 InterPro	573
UniProtKB:A0A8M3B0T6 InterPro	531