Gene

flcn

ID

ZDB-GENE-060421-3470

Name

folliculin

Symbol

flcn Nomenclature History

Previous Names

wu:fe38g11
zgc:136982

Type

protein_coding_gene

Location

Chr: 16 Mapping Details/Browsers

Description

Predicted to contribute to GTPase activator activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; positive regulation of GTPase activity; and positive regulation of signal transduction. Predicted to localize to cytosol. Used to study Birt-Hogg-Dube syndrome. Human ortholog(s) of this gene implicated in Birt-Hogg-Dube syndrome; colorectal cancer; primary spontaneous pneumothorax; and renal cell carcinoma. Is expressed in brain; hatching gland; pectoral fin bud; retina; and tail bud. Orthologous to human FLCN (folliculin).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Kenyon et al., 2016

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 4 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With flcn Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Birt-Hogg-Dube syndrome	Alliance	Birt-Hogg-Dube syndrome	135150
colorectal cancer	Alliance	Colorectal cancer, somatic	114500
nonpapillary renal cell carcinoma	Alliance	Renal carcinoma, chromophobe, somatic	144700
primary spontaneous pneumothorax	Alliance	Pneumothorax, primary spontaneous	173600

Associated With flcn Via Experimental Models

Human Disease	Fish	Conditions	Citations
Birt-Hogg-Dube syndrome	AB + MO3-flcn	standard conditions	Kenyon et al., 2016

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR032035	Folliculin, DENN domain
Domain	IPR037520	Folliculin/SMCR8, longin domain
Domain	IPR037521	Folliculin/SMCR8, tripartite DENN domain
Family	IPR021713	Folliculin
Homologous_superfamily	IPR044886	Folliculin, DENN domain, C-terminal superfamily

Domain Details Per Protein

Protein	Length	Folliculin	Folliculin, DENN domain	Folliculin, DENN domain, C-terminal superfamily	Folliculin/SMCR8, longin domain	Folliculin/SMCR8, tripartite DENN domain
UniProtKB:F1R3E5 InterPro	558
UniProtKB:Q1RLN8 InterPro	558

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	flcn-201 (1) Ensembl	Ensembl	2,468 nt	Select Tool
mRNA	flcn-202 (1) Ensembl	Ensembl	780 nt	Select Tool
mRNA	flcn-203 (1) Ensembl	Ensembl	3,804 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations