Gene
mpl
- ID
- ZDB-GENE-060421-1
- Name
- MPL proto-oncogene, thrombopoietin receptor
- Symbol
- mpl Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Involved in thrombocyte differentiation. Predicted to localize to integral component of membrane. Is expressed in blood; nucleate erythrocyte; thrombocyte; and ventral wall of dorsal aorta. Used to study congenital amegakaryocytic thrombocytopenia. Human ortholog(s) of this gene implicated in congenital amegakaryocytic thrombocytopenia; essential thrombocythemia; myelofibrosis; thrombocytopenia; and thrombocytosis. Orthologous to human MPL (MPL proto-oncogene, thrombopoietin receptor).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- 10 figures from 10 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
congenital amegakaryocytic thrombocytopenia | Alliance | Amegakaryocytic thrombocytopenia, congenital, 1 | 604498 |
essential thrombocythemia | Alliance | Thrombocythemia 2 | 601977 |
myelofibrosis | Alliance | Myelofibrosis with myeloid metaplasia, somatic | 254450 |
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Length | Fibronectin type III | Fibronectin type III superfamily | Growth hormone/erythropoietin receptor, ligand binding | Immunoglobulin-like fold | Zinc finger C2H2-type |
---|---|---|---|---|---|---|
UniProtKB:A0A8M2BDQ1
|
641 | |||||
UniProtKB:Q6EIY6
|
614 |
Interactions and Pathways
No data available
Plasmids
No data available