Gene
pdyn
- ID
- ZDB-GENE-060417-1
- Name
- prodynorphin
- Symbol
- pdyn Nomenclature History
- Previous Names
-
- fj38c03
- wu:fj38c03
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Enables opioid receptor binding activity. Predicted to be involved in chemical synaptic transmission; neuropeptide signaling pathway; and sensory perception. Predicted to be located in extracellular region. Predicted to be active in several cellular components, including axon terminus; dendrite; and neuronal cell body. Is expressed in brain and hypothalamus. Human ortholog(s) of this gene implicated in spinocerebellar ataxia type 23 and temporal lobe epilepsy. Orthologous to human PDYN (prodynorphin).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| spinocerebellar ataxia type 23 | Alliance | Spinocerebellar ataxia 23 | 610245 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Opioid neuropeptide precursor | Proenkephalin B |
|---|---|---|---|
|
UniProtKB:A0A8M3B6F1
|
253 | ||
|
UniProtKB:Q6JT77
|
252 | ||
|
UniProtKB:A0A8M3AYT0
|
261 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-189P6 | ZFIN Curated Data | |
| Contained in | BAC | CH73-302A13 | ZFIN Curated Data | |
| Contained in | BAC | CH211-136O14 | Gonzalez-Nunez et al., 2007 | |
| Encodes | EST | fj38c03 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001001831 (1) | 1281 nt | ||
| Genomic | GenBank:CU914487 (2) | 118103 nt | ||
| Polypeptide | UniProtKB:A0A8M3AYT0 (1) | 261 aa |
- Cansiz, D., Unal, I., Beler, M., Ustundag, U.V., Ak, E., Emekli-Alturfan, E., Alturfan, A.A. (2023) The Effect of Acetic Acid-Induced Pain in Parkinson's Disease Model in Zebrafish. Neurotoxicology. 99:14-23
- Bian, Y., Wang, X., Liang, J.H., Li, L., Wu, X., Tang, B., Leung, G.P., Lee, S.M. (2021) The development of behavioral sensitization induced by a single morphine exposure in adult zebrafish (Danio rerio). Progress in neuro-psychopharmacology & biological psychiatry. 113:110456
- Zhang, W., Li, Y., Chen, S., Zhang, C., Chen, L., Peng, G. (2021) nr0b1 (DAX1) loss of function in zebrafish causes hypothalamic defects via abnormal progenitor proliferation and differentiation. Journal of genetics and genomics = Yi chuan xue bao. 49(3):217-229
- Raj, B., Farrell, J.A., Liu, J., El Kholtei, J., Carte, A.N., Navajas Acedo, J., Du, L.Y., McKenna, A., Relić, Đ., Leslie, J.M., Schier, A.F. (2020) Emergence of Neuronal Diversity during Vertebrate Brain Development. Neuron. 108(6):1058-1074.e6
- Schredelseker, T., Veit, F., Dorsky, R.I., Driever, W. (2020) Bsx Is Essential for Differentiation of Multiple Neuromodulatory Cell Populations in the Secondary Prosencephalon. Frontiers in neuroscience. 14:525
- Teixeira, C.M.M., Correa, C.N., Iwai, L.K., Ferro, E.S., Castro, L.M. (2019) Characterization of Intracellular Peptides from Zebrafish (Danio rerio) Brain. Zebrafish. 16(3):240-251
- Pandey, S., Shekhar, K., Regev, A., Schier, A.F. (2018) Comprehensive Identification and Spatial Mapping of Habenular Neuronal Types Using Single-Cell RNA-Seq. Current biology : CB. 28(7):1052-1065.e7
- Van Camp, K.A., Baggerman, G., Blust, R., Husson, S.J. (2017) Peptidomics of the zebrafish Danio rerio: In search for neuropeptides. Journal of proteomics. 150:290-296
- Liu, J., Merkle, F.T., Gandhi, A.V., Gagnon, J.A., Woods, I.G., Chiu, C.N., Shimogori, T., Schier, A.F., Prober, D.A. (2015) Evolutionarily conserved regulation of hypocretin neuron specification by Lhx9. Development (Cambridge, England). 142(6):1113-24
- Gagnon, J.A., Valen, E., Thyme, S.B., Huang, P., Ahkmetova, L., Pauli, A., Montague, T.G., Zimmerman, S., Richter, C., Schier, A.F. (2014) Efficient Mutagenesis by Cas9 Protein-Mediated Oligonucleotide Insertion and Large-Scale Assessment of Single-Guide RNAs. PLoS One. 9:e98186
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