Gene
st6gal1
- ID
- ZDB-GENE-060322-3
- Name
- ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
- Symbol
- st6gal1 Nomenclature History
- Previous Names
-
- zgc:136454
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to enable beta-galactoside alpha-2,6-sialyltransferase activity. Predicted to be involved in sialylation. Predicted to act upstream of or within protein glycosylation. Predicted to be located in membrane. Predicted to be active in Golgi apparatus. Is expressed in gill; liver; nervous system; and pleuroperitoneal region. Orthologous to human ST6GAL1 (ST6 beta-galactoside alpha-2,6-sialyltransferase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Glycosyl transferase family 29 | GT29-like superfamiliy |
|---|---|---|---|
|
UniProtKB:F1QMH5
|
495 | ||
|
UniProtKB:F1QK50
|
484 | ||
|
UniProtKB:Q6KB61
|
484 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
st6gal1-201
(1)
|
Ensembl | 1,996 nt | ||
| mRNA |
st6gal1-202
(1)
|
Ensembl | 2,121 nt | ||
| mRNA |
st6gal1-203
(1)
|
Ensembl | 1,004 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-241E20 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:136454 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001003853 (1) | 1455 nt | ||
| Genomic | GenBank:CT574573 (1) | 142754 nt | ||
| Polypeptide | UniProtKB:F1QMH5 (1) | 495 aa |
- Yamakawa, N., Vanbeselaere, J., Chang, L.Y., Yu, S.Y., Ducrocq, L., Harduin-Lepers, A., Kurata, J., Aoki-Kinoshita, K.F., Sato, C., Khoo, K.H., Kitajima, K., Guerardel, Y. (2018) Systems glycomics of adult zebrafish identifies organ-specific sialylation and glycosylation patterns. Nature communications. 9:4647
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Vanbeselaere, J., Chang, L.Y., Harduin-Lepers, A., Fabre, E., Yamakawa, N., Slomianny, C., Biot, C., Khoo, K.H., and Guerardel, Y. (2012) Mapping the expressed glycome and glycosyltransferases of zebrafish liver cells as a relevant model system for glycosylation studies. Journal of Proteome Research. 11(4):2164-2177
- Harduin-Lepers, A. (2010) Comprehensive Analysis of sialyltransferases in vertebrate genomes.. Glycobiology. 2010:2:29-61
- Petit, D., Mir, A., Petit, J., Thisse, C., Delannoy, P., Oriol, R., Thisse, B., Harduin-Lepers, A. (2010) Molecular phylogeny and functional genomics of beta-galactoside alpha2,6-sialyltransferases that explain ubiquitous expression of st6gal1 gene in amniotes. The Journal of biological chemistry. 285:38399-38414
- Harduin-Lepers, A., Mollicone, R., Delannoy, P., and Oriol, R. (2005) The animal sialyltransferases and sialyltransferase-related genes: a phylogenetic approach. Glycobiology. 15(8):805-817
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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