Gene
kcnj8
- ID
- ZDB-GENE-060308-1
- Name
- potassium inwardly rectifying channel subfamily J member 8
- Symbol
- kcnj8 Nomenclature History
- Previous Names
-
- Kir6.1 (1)
- si:dkey-183c2.2
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to enable ATP-activated inward rectifier potassium channel activity. Predicted to be involved in potassium ion import across plasma membrane and regulation of monoatomic ion transmembrane transport. Predicted to act upstream of or within potassium ion transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Used to study hypertrichotic osteochondrodysplasia Cantu type. Orthologous to human KCNJ8 (potassium inwardly rectifying channel subfamily J member 8).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 5 figures from Tessadori et al., 2018
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| hypertrichotic osteochondrodysplasia Cantu type | kcnj8hu11872/+ | standard conditions | Tessadori et al., 2018 |
1 - 1 of 1
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR040445 | Potassium channel, inwardly rectifying, transmembrane domain |
| Domain | IPR041647 | Inward rectifier potassium channel, C-terminal |
| Family | IPR003278 | Potassium channel, inwardly rectifying, Kir6.1 |
| Family | IPR016449 | Potassium channel, inwardly rectifying, Kir |
| Homologous_superfamily | IPR013518 | Potassium channel, inwardly rectifying, Kir, cytoplasmic |
1 - 5 of 6 Show all
Domain Details Per Protein
| Protein | Length | Immunoglobulin E-set | Inward rectifier potassium channel, C-terminal | Potassium channel, inwardly rectifying, Kir | Potassium channel, inwardly rectifying, Kir6.1 | Potassium channel, inwardly rectifying, Kir, cytoplasmic | Potassium channel, inwardly rectifying, transmembrane domain |
|---|---|---|---|---|---|---|---|
|
UniProtKB:Q5RH88
|
416 |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-183C2 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194867 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194896 | ZFIN Curated Data |
1 - 3 of 3
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001030153 (1) | 1251 nt | ||
| Genomic | GenBank:BX571719 (1) | 111614 nt | ||
| Polypeptide | UniProtKB:Q5RH88 (1) | 416 aa |
- de Bakker, D.E.M., Bouwman, M., Dronkers, E., Simões, F.C., Riley, P.R., Goumans, M.J., Smits, A.M., Bakkers, J. (2021) Prrx1b restricts fibrosis and promotes Nrg1-dependent cardiomyocyte proliferation during zebrafish heart regeneration. Development (Cambridge, England). 148(19):
- Silic, M.R., Murata, S.H., Park, S.J., Zhang, G. (2021) Evolution of inwardly rectifying potassium channels and their gene expression in zebrafish embryos. Developmental Dynamics : an official publication of the American Association of Anatomists. 251(4):687-713
- Singareddy, S.S., Roessler, H.I., McClenaghan, C., Ikle, J., Tryon, R., van Haaften, G., Nichols, C.G. (2021) ATP-sensitive potassium channels in zebrafish cardiac and vascular smooth muscle. The Journal of physiology. 600(2):299-312
- Lawson, N.D., Li, R., Shin, M., Grosse, A., Yukselen, O., Stone, O.A., Kucukural, A., Zhu, L. (2020) An improved zebrafish transcriptome annotation for sensitive and comprehensive detection of cell type-specific genes. eLIFE. 9:
- Luo, X., Chen, L., Zhang, Y., Liu, J., Xie, H. (2020) Developmental and cardiac toxicities of propofol in zebrafish larvae. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 237:108838
- Tessadori, F., Roessler, H.I., Savelberg, S.M.C., Chocron, S., Kamel, S.M., Duran, K.J., van Haelst, M.M., van Haaften, G., Bakkers, J. (2018) Effective CRISPR/Cas9-based nucleotide editing in zebrafish to model human genetic cardiovascular disorders. Disease models & mechanisms. 11(10):
- Emfinger, C.H., Welscher, A., Yan, Z., Wang, Y., Conway, H., Moss, J.B., Moss, L.G., Remedi, M.S., Nichols, C.G. (2017) Expression and function of ATP-dependent potassium channels in zebrafish islet β-cells. Royal Society open science. 4:160808
- Zhang, C., Miki, T., Shibasaki, T., Yokokura, M., Saraya, A., and Seino, S. (2006) Identification and characterization of a novel member of the ATP-sensitive K+ channel subunit, Kir6.3, in zebrafish. Physiological Genomics. 24(3):290-297
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
1 - 9 of 9
Show