Gene
roraa
- ID
- ZDB-GENE-060306-2
- Name
- RAR-related orphan receptor A, paralog a
- Symbol
- roraa Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to have several functions, including nuclear receptor activity; steroid hormone receptor activity; and zinc ion binding activity. Involved in cerebellum morphogenesis and positive regulation of gene expression. Predicted to localize to nucleus. Is expressed in brain and eye. Orthologous to human RORA (RAR related orphan receptor A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 20 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- dq017624 (19 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Guissart et al., 2018
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Intellectual developmental disorder with or without epilepsy or cerebellar ataxia | 618060 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000536 | Nuclear hormone receptor, ligand-binding domain |
| Domain | IPR001628 | Zinc finger, nuclear hormone receptor-type |
| Domain | IPR044101 | Retinoid-related orphan receptors, DNA-binding domain |
| Family | IPR001723 | Nuclear hormone receptor |
| Family | IPR003079 | Nuclear receptor ROR |
| Homologous_superfamily | IPR013088 | Zinc finger, NHR/GATA-type |
| Homologous_superfamily | IPR035500 | Nuclear hormone receptor-like domain superfamily |
Domain Details Per Protein
| Protein | Length | Nuclear hormone receptor | Nuclear hormone receptor, ligand-binding domain | Nuclear hormone receptor-like domain superfamily | Nuclear receptor ROR | Retinoid-related orphan receptors, DNA-binding domain | Zinc finger, NHR/GATA-type | Zinc finger, nuclear hormone receptor-type |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:F1QLY4
|
468 | |||||||
|
UniProtKB:A0A8M6YWJ2
|
519 |
Interactions and Pathways
No data available
Plasmids
No data available