Gene
ar
- ID
- ZDB-GENE-060131-1
- Name
- androgen receptor
- Symbol
- ar Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Exhibits androgen binding activity; nuclear receptor activity; and steroid hormone receptor activity. Involved in gamete generation; male courtship behavior; and male gonad development. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in several diseases, including attention deficit hyperactivity disorder; conduct disorder; disorders of sexual development (multiple); reproductive organ cancer (multiple); and spinal muscular atrophy (multiple). Is expressed in several structures, including digestive system; heart; male organism; nervous system; and pleuroperitoneal region. Orthologous to human AR (androgen receptor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 34 figures from 20 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- ay510448 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- 26 figures from 6 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| androgen insensitivity syndrome | Alliance | Androgen insensitivity | 300068 |
| hypospadias | Alliance | Hypospadias 1, X-linked | 300633 |
| Kennedy's disease | Alliance | Spinal and bulbar muscular atrophy, X-linked 1 | 313200 |
| partial androgen insensitivity syndrome | Alliance | Androgen insensitivity, partial, with or without breast cancer | 312300 |
| {Prostate cancer, susceptibility to} | 301120 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000536 | Nuclear hormone receptor, ligand-binding domain |
| Domain | IPR001628 | Zinc finger, nuclear hormone receptor-type |
| Family | IPR001723 | Nuclear hormone receptor |
| Family | IPR050200 | Nuclear hormone receptor family NR3 subfamily |
| Homologous_superfamily | IPR013088 | Zinc finger, NHR/GATA-type |
| Homologous_superfamily | IPR035500 | Nuclear hormone receptor-like domain superfamily |
Domain Details Per Protein
| Protein | Length | Nuclear hormone receptor | Nuclear hormone receptor family NR3 subfamily | Nuclear hormone receptor, ligand-binding domain | Nuclear hormone receptor-like domain superfamily | Zinc finger, NHR/GATA-type | Zinc finger, nuclear hormone receptor-type |
|---|---|---|---|---|---|---|---|
|
UniProtKB:A4GT83
|
868 |
Interactions and Pathways
No data available
Plasmids
No data available